Possible Causes for Lymphopenia Severe Combined Immunodeficiency A full blood count revealed profound lymphopenia. The child was diagnosed with adenosine deaminase deficiency, a rare cause of severe combined immunodeficiency (SCID). [ncbi.nlm.nih.gov] METHODS: Between May 1, 2010 and December 31, 2011, the National Taiwan University Hospital Newborn Screening Center screened all newborns for T-cell lymphopenia by measuring [ncbi.nlm.nih.gov] Recognition of the characteristic lymphopenia of SCID can facilitate early diagnosis. [ncbi.nlm.nih.gov] Cartilage Hair Hypoplasia Here, we present a case of CHH with mild skeletal changes and immunological findings associated with recurrent otitis media, neutropenia, and lymphopenia. [ncbi.nlm.nih.gov] Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov] These data suggest that lymphopenia and immunodeficiency in CHH may be, at least in part, due to increased apoptosis of T cells, possibly through the Fas/ FasL signaling pathway [ncbi.nlm.nih.gov] Congenital AIDS One of the early clues to an acquired immunodeficiency state is the development of absolute lymphopenia. [hemonc.mhmedical.com] […] secretion of tolerogenic cytokines Cytopenias Decreased cellular immunity and anergy Stress-induced nonspecific immune activation Infectious diseases: HIV infection T-cell lymphopenia [incodom.kr] […] recessive) IL-2RG(X-linked) Oral candidiasis, Pneumocystis jirovecii pneumonia, diarrhea before 6 months, failure to thrive, graft vs host disease, absent thymic shadow, lymphopenia [msdmanuals.com] Ataxia-Telangiectasia Syndrome The patient presented at age 3 years with a perineal cellulitis associated with profound neutropenia and T-cell lymphopenia. [ncbi.nlm.nih.gov] They have immunological abnormalities including immunoglobulin and antibody deficiencies and lymphopenia. [ncbi.nlm.nih.gov] Lymphopenia affected 71% of patients, with reduced B-lymphocyte number in 75%, CD4 T lymphocytes in 69%, and CD8 T lymphocytes in 51%. [ncbi.nlm.nih.gov] Ehrlichiosis In this study, we compared the immune responses in two patients with mild/non fatal and severe/fatal HME who had marked lymphopenia, thrombocytopenia and elevated liver enzymes [ncbi.nlm.nih.gov] Common laboratory abnormalities included thrombocytopenia (94%), elevated aspartate aminotransferase (90%), elevated alanine aminotransferase (74%), hypoalbuminemia (65%), lymphopenia [ncbi.nlm.nih.gov] Clinical laboratory findings may include thrombocytopenia, lymphopenia, leucopenia, and elevated liver enzymes. [dhs.wisconsin.gov] Childhood Hodgkin Lymphoma The complete cell blood count may show neutrophilia or eosinophilia, lymphopenia or monocytosis, anemia or thrombocytopenia. [symptoma.com] Angioimmunoblastic T-Cell Lymphoma It is characterized by acute onset, severe constitutional symptoms, cervical or generalized lymphadenopathy, lymphopenia, and polyclonal hypergammaglobulinemia, all of which [ncbi.nlm.nih.gov] Lymphopenia was seen in 2 patients. 4. Lymphocytes with azure granules which encompass T-suppressors were found to exceed normal values by a factor of 15. 5. [scipers.com] ( eMedicine ) Laboratory Polyclonal hypergammaglobulinemia and autoimmune hemolytic anemia ( Hsi: Hematopathology, Second Edition, 2012 ) Eosinophilia, thrombocytopenia, lymphopenia [pathologyoutlines.com] Middle East Respiratory Syndrome All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine [ncbi.nlm.nih.gov] Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia [ncbi.nlm.nih.gov] Lymphopenia was the most common finding in a cohort of 157 patients with SARS. [doi.org] COVID-19 In 63% of the patients, lymphopenia was observed. Abnormal findings on chest CTs were observed for all 41 patients. [contagionlive.com] […] non-specific: fever myalgia malaise non-productive cough pleuritic pain dyspnea Laboratory tests The most common findings in a study of 138 hospitalized patients were 13: lymphopenia [radiopaedia.org] She was tachypneic (30bpm), with lymphopenia and low oxygen saturation (SpO2 85%). [radiologyassistant.nl] Phlebotomus Fever Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. [ncbi.nlm.nih.gov] Acquired Immunodeficiency Syndrome What about the observed lymphopenia? [forbes.com] Lymphopenia was not common, as it is in adult patients. [nejm.org] He was hospitalized again in April with fever, splenomegaly, anemia, and lymphopenia. [cdc.gov] Disseminated Histoplasmosis […] protein - 40 mg/L (normal [7] based on malar rash, photosensitivity, nonerosive arthritis, positive ANA, serositis (pleural effusion), and hematological disorder (leukopenia, lymphopenia [e-ijd.org] Chronic Eosinophilic Leukemia As expected, all patients developed lymphopenia during treatment with alemtuzumab. [clincancerres.aacrjournals.org] Tonsillitis Tonsillitis A culture positive case of Streptococcal pharyngitis with typical tonsillar exudate Pronunciation Template:IPAc-I ya ɒ TON-si-LY-tis Specialty Infectious disease Symptoms Sore throat, fever, enlargement of the tonsils, trouble swallowing, large lymph nodes around the neck[1] Complications Peritonsillar[…] [en.wikipedia.org] Intestinal Lymphangiectasia The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov] […] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov] […] in moths) Lenzhofer [ 10 ] (1993) Male 26 Ileus, epigastric pain of sudden onset and oedema of the extremities Unknown Severe hypoproteinaemia, low IgG concentration and lymphopenia [academic.oup.com] Laron Syndrome with Immunodeficiency Immunodeficiency is characterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. [orpha.net] Standard analyses do not usually show any anomalies, but moderate lymphopenia and hypergammaglobulinemia have been reported. [symptoma.com] In patients with STAT5B deficiency, moderate lymphopenia with lack of CD3+, CD4+, and CD8+ T cells, CD4+/CD25+ regulatory T cells, γδ T cells, and NK cells has been described [symptoma.com] Lymphopenia lymphopenia in 10%. [doi.org] Lymphopenia (Lymphocytopenia) Rate this post Lymphopenia Definition Lymphopenia or lymphocytopenia is a condition that involves a decrease in the level of serum lymphocytes [healthosphere.com] There is surprisingly little literature on lymphopenia in SLE, despite its common occurrence in this disorder. 24, 25, 45, 46 Lymphopenia is well known to predispose to infections [doi.org] Idiopathic CD4 Lymphocytopenia Causes of Lymphopenia Lymphopenia can be caused by many conditions, including infection and medication side effect. At times, the condition may only affect lymphocytes. [verywell.com] It may be discovered that some of the patients diagnosed during infancy with idiopathic T-cell lymphopenia represent the earliest presentation of the idiopathic CD4-cell lymphopenia [frontiersin.org] I would also consider an ANA since SLE may result in lymphopenia. [aaaai.org] Complement Factor I Deficiency Sclerosing cholangitis Zeta-chain-associated protein-70 (ZAP-70) deficiency ZAP70 AR CD8 lymphopenia CD4 hypoproliferation CD8 deficiency TAP1/TAP2/TAPBP AR CD8 lymphopenia [oncologynurseadvisor.com] Decreased T Cell receptors Mild to moderate Lymphopenia. [pedemmorsels.com] The infant's mother, a 29-year-old resident of San Francisco, is a prostitute and intravenous drug abuser with a history of oral candidiasis and mild lymphopenia. [cdc.gov] Immunodeficiency Lymphopenia and delayed cutaneous anergy remitted during treatment with a completely FULL TEXT [annals.org] RBC adenosine deaminase assay Severe lymphopenia Levels are low in a specific form of SCID. [msdmanuals.com] Improvement of the candidiasis was associated with remission of the delayed cutaneous anergy and lymphopenia. [annals.org] Adenosine Deaminase Deficiency She had frequent infections, lymphopenia, and recurrent hepatitis as a child but did relatively well in her second and third decades. [ncbi.nlm.nih.gov] Lymphopenia is profound (most severe of all forms of SCID), with absent cellular and humeral immune function. 2. [accessanesthesiology.mhmedical.com] Abstract In most instances, marked deficiency of the purine catabolic enzyme adenosine deaminase results in lymphopenia and severe combined immunodeficiency disease. [ncbi.nlm.nih.gov] Leukopenia OBJECTIVE: To systematically review the available evidence to evaluate (1) the prevalence and degree of leukopenia, lymphopenia, and neutropenia in patients with systemic [ncbi.nlm.nih.gov] Lymphopenia and GC use are known risk factors for infections in SLE patients. [consultqd.clevelandclinic.org] […] designed to obliterate leukocyte population e.g. chemotherapy or radiotherapy It can be subdivided according to the white cell population that is (most) affected: neutropenia lymphopenia [gpnotebook.com] Acute Infectious Lymphocytosis - Lab findings: lymphopenia then lymphocytosis, thrombocytopenia, elevated transaminase, depressed CD4 count, HIV AB usually negative-- so check Viral load. [errolozdalga.com] McBride M: CD4 lymphopenia in elderly patients [letter, comment]. Lancet 347:911, 1996. 148. [medtextfree.wordpress.com] Decreased Lymphocytes: Lymphopenia. [doctorslounge.com] Primary Intestinal Lymphangiectasia The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov] […] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov] […] rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia [ncbi.nlm.nih.gov] Severe Combined Immunodeficiency with Low T- and B-Cell Numbers […] clinical context to support the T-cell lymphopenia. [aacc.org] Its clinical manifestations are growth retardation, dysmorphic features, malformations, and severe B- and T-cell lymphopenia. [ncbi.nlm.nih.gov] CHARGE syndrome, and idiopathic T-cell lymphopenia. [aacc.org] Purine-Nucleoside Phosphorylase Deficiency Progressive lymphopenia, ataxia, and developmental delay led to diagnosis. Umbilical cord blood transplantation corrected the immunodeficiency. [ncbi.nlm.nih.gov] There is severe lymphopenia with decreased absolute numbers of T and B lymphocytes. [ncbi.nlm.nih.gov] A severe lymphopenia exists; however, clinical symptoms of an immune deficiency did not become apparent until the age of 4 yr. [ncbi.nlm.nih.gov] Immunodeficiency Type 23 We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [uniprot.org] […] received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia and lymphopenia [uniprot.org] Good Syndrome A complete blood count (CBC) is mandatory and should be obtained right away, with anemia, leukopenia (either granulocytopenia or lymphopenia) and/or thrombocytopenia being [symptoma.com] Evaluation of his immune status during the terminal illness revealed hypogammaglobulinemia and lymphopenia consistent with a diagnosis of Good's syndrome (immunodeficiency [ncbi.nlm.nih.gov] Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4+ T cell lymphopenia, surprisingly this complication has not been reported in [ncbi.nlm.nih.gov] Schimke Immunoosseous Dysplasia He had recurrent lymphopenia with low CD4/CD8 ratio. However lymphopenia respond to granulocyte colony-stimulating factor (G-CSF), he died with pneumonia and sepsis. [ijp.mums.ac.ir] We report on a 16-year-old girl with spondyloepiphyseal dysplasia, nephrotic syndrome, lymphopenia, and signs of defective cellular immunity. [ncbi.nlm.nih.gov] The high signal proteinuria with progressive renal two, cytochemical and microbio- on left lentiform nucleus re- failure, T cell lymphopenia and logical CSF analysis disclosed [deepdyve.com] Protein-Losing Enteropathy The diagnosis of lupus was established based on the presence of lymphopenia, proteinuria, ANA, and positive autoantibodies (anti-Sm, anti-DNA, and anti-Ro). [ncbi.nlm.nih.gov] It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. [ncbi.nlm.nih.gov] All patients with PLE had lymphopenia compared with 25% of controls (P = .01). [ncbi.nlm.nih.gov]
