Multiple Pulmonary Nodules: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Multiple Pulmonary Nodules

Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use [ncbi.nlm.nih.gov]

Chest X-ray images showed multiple pulmonary nodules. Transbronchial lung biopsy specimens showed lymphocytic infiltrates but no malignant cells. [ncbi.nlm.nih.gov]

Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. [karger.com]

Cryptococcosis

pulmonary nodules or masses, which mimics primary or metastatic malignancy. [5], [9], [10] A large solitary cryptococcoma replacing the majority of a lobe, as seen in our [ccij-online.org]

[…] or multiple pulmonary nodules or masses, seen in 10 (83%) of the 12 patients. [ajronline.org]

RESULTS: The most common CT finding was pulmonary nodules ( n = 9). Multiple nodules ( n = 7) were more common than solitary nodules ( n = 2). [pubs.rsna.org]

Metastatic Renal Cell Carcinoma

Multiple pulmonary nodules as described. Figure 5. [scmr.org]

The patient was advised to consider a below-knee amputation to prevent further metastases, but ct imaging revealed multiple new bilateral pulmonary nodules. [current-oncology.com]

Pulmonary metastases are usually asymptomatic (90% of cases). On CT images, they manifest as multiple nodules (75.6% of cases) or solitary nodules (30.5% of cases) (24). [pubs.rsna.org]

Pulmonary Metastasis

She was examined for multiple pulmonary nodules mimicking pulmonary metastasis that were detected with chest radiography and computed tomography of the thorax. [ncbi.nlm.nih.gov]

We present a case of histoplasmosis with multiple pulmonary nodules in a patient with a history of melanoma. [ncbi.nlm.nih.gov]

Nodules  May be solitary or multiple.  Rounded nodules of variable sizes ranging from few millimeters to few centimeters with well-defined margin. 75 % - multiple pulmonary [slideshare.net]

Pulmonary Lymphomatoid Granulomatosis

This demonstrates the potential for diagnostic difficulty in a case presentation of multiple pulmonary nodules. [ncbi.nlm.nih.gov]

Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. [karger.com]

A repeat CT scan showed the decreased size of the lung nodules. [ncbi.nlm.nih.gov]

Pulmonary Syphilis

Chest CT scan and 18 F-fluorodeoxyglucose (FDG) PET/CT showed multiple pulmonary nodules mimicking pulmonary hematogenous metastases. [oalib.com]

All of these cases presented with multiple pulmonary nodules. [err.ersjournals.com]

Clinical Infectious Diseases, Feb 2006 We report the case of a homosexual, HIV-positive man with typical secondary syphilis and multiple excavated pulmonary subpleural nodules [paperity.org]

Pulmonary Cryptococcosis

Pulmonary cryptococcosis should be considered in the differential diagnosis of solitary or multiple pulmonary nodules (with or without associated CT halo sign), particularly [journals.lww.com]

The most common radiographic abnormalities were multiple pulmonary nodules or masses, seen in 8 and 5 cases of patients respectively. 14 patients received specific therapy [ncbi.nlm.nih.gov]

CONCLUSION: Pulmonary cryptococcosis should be considered in the differential diagnosis of solitary or multiple pulmonary nodules. [ncbi.nlm.nih.gov]

Pulmonary Non-Tuberculous Mycobacterial Infection

These organisms are commonly recovered on sputum or bronchoscopic cultures obtained as part of an evaluation for an abnormal CT scan of the chest demonstrating multiple pulmonary [consultqd.clevelandclinic.org]

NTM pulmonary infection could be suspected in selected patients who have multiple pulmonary nodules combined with diffuse bronchiectasis on the HRCT scan. [thorax.bmj.com]

In some individuals, the disease will present as a single or multiple small masses in the lungs (single or multiple pulmonary nodules) or as hypersensitivity pneumonitis, [rarediseases.org]

Pulmonary Nocardiosis

The typical clinical findings are those of bilateral multiple pulmonary nodules in young or middle aged Caucasian women. [ncbi.nlm.nih.gov]

[…] low attenuation areas with or without cavitation, multiple pulmonary nodules, pleural effusion, and chest wall extension. [ncbi.nlm.nih.gov]

We report a case of pulmonary nocardiosis with bilateral multiple cavitary nodules in a HIV-negative 60-year-old man with nephrotic syndrome who was receiving corticosteroid [ncbi.nlm.nih.gov]

Baritosis

multiple small hyperdense pulmonary nodules pneumoconiosis Promoted articles (advertising) [radiopaedia.org]

For extremely dense nodules on plain film consider: pulmonary stannosis pulmonary alveolar microlithiasis For a broader differential on plain film consider: differential for [radiopaedia.org]

Light Chain Disease

In all cases there were single or multiple pulmonary nodules, in one case associated with cysts. [jcp.bmj.com]

Kijner CM, Yousem SA: Systemic light chain deposition disease presenting as multiple pulmonary nodules. Am J Surg Pathol, 12: 405–413, 1988. [link.springer.com]

The pulmonary nodules were multiple or unique and varied in size from 0.7–4 cm. [erj.ersjournals.com]

Kaposi Sarcoma of the Lung

Computed Tomography revealed multiple opacities and pulmonary nodules. Biopsy of the skin lesion confirmed Kaposi sarcoma. [austinpublishinggroup.com]

She underwent high-resolution chest computed tomography that showed new multiple subcentimeter pulmonary nodules, diffusely dispersed throughout both lungs ( Fig. 1 A). [archbronconeumol.org]

Chest x-ray showed multiple nodular opacities in both lung fields. Computed tomography of the chest revealed multiple diffuse opacities and pulmonary nodules (Figure 1). [austinpublishinggroup.com]

Pulmonary Candidiasis

Computed tomography scans revealed multiple pulmonary nodules and hilar and mediastinal enlarged lymph nodes. [ncbi.nlm.nih.gov]

Pulmonary cryptococcosis. A Multiple pulmonary subpleural nodules seen at autopsy. [isradiology.org]

Chest radiograph showing multiple pulmonary nodules. [emedicine.medscape.com]

Pulmonary Clear Cell Tumor

MeSH Descriptor Source: MeSH 2019 deskriptory Main Heading mnohočetné plicní uzly English Heading Multiple Pulmonary Nodules See (Czech) mnohočetné plicní noduly [cze0037457 [medvik.cz]

A chest CT revealed multiple pulmonary nodules bilaterally, the largest measuring 15 mm. [spandidos-publications.com]

Cryptogenic organizing pneumonia (formerly known as BOOP) may present with fever, malaise, and a single nodule or multiple pulmonary nodules that are indistinguishable from [pulmonologyadvisor.com]

Parasitic Lung Disease

Beryllium-associated lung disease may also present with multiple pulmonary nodules that on imaging may mimic sarcoidosis. [icnet.uk]

Both conditions can develop into ‘progressive massive fibrosis’ (PMF) or multiple pulmonary nodules that range in size from 1 to 10 cm. [icnet.uk]

Caplan’s disease is a combination of rheumatoid arthritis and coal-worker’s pneumoconiosis that manifests with multiple pulmonary nodules. [icnet.uk]

Lymphocytic Interstitial Pneumonia

To our knowledge this is the first report of pediatric pSS with lymphocytic interstitial pneumonia and multiple pulmonary nodules on chest radiograph. [ncbi.nlm.nih.gov]

pulmonary nodules (may be cavitary) Skin rash Central nervous system (CNS) disease Hypersensitivity Pneumonitis Appropriate antigen exposure Diffuse ground-glass opacities [radiologykey.com]

[…] adenopathy Hyaline vascular form: Nodes have intense contrast enhancement Lungs less likely to be abnormal (if abnormal may be due to co-existing LIP) Lymphomatoid Granulomatosis Multiple [radiologykey.com]

Epithelioid Hemangioendothelioma

Imaging revealed bilobar liver lesions consistent with HEHE, a discrete left lobe lesion suspected as HCC, and multiple pulmonary nodules. [ncbi.nlm.nih.gov]

We also estimated overall survival.The most common pattern of thoracic involvement was multiple pulmonary nodules (n = 10), followed by parenchymal tumor with pleural invasion [ncbi.nlm.nih.gov]

Chest computed tomography (CT) performed during a routine cancer screening revealed multiple small pulmonary nodules in a 50-year-old man who had previously undergone endoscopic [ncbi.nlm.nih.gov]

Pulmonary Histiocytosis X

Multiple cavitating pulmonary nodules due to eosinophilic granuloma. [kjim.org]

[…] differential of multiple pulmonary nodules and differential of miliary opacities for more comprehensive lists. [radiopaedia.org]

As pulmonary histiocytosis X progresses, the nodules decrease in number, leaving multiple thin-walled cysts. [ncbi.nlm.nih.gov]

Subarachnoid Abscess

Chest radiograph showed bilateral multiple pulmonary nodules, some of which contained a cavity. Blood culture was positive for Streptococcus constellatus. [ncbi.nlm.nih.gov]

Extrapelvic Endometriosis

Parathyroid Cancer

CT imaging identified no visible disease in the neck but multiple pulmonary nodules consistent with metastatic disease were noted (Figure 2a ). [frontiersin.org]

In a search for distant metastases, the patient underwent pulmonary computerized tomography, and multiple pulmonary nodules were found ( Figure 1 ). [scielo.br]

An abdominal ultrasound showed multiple renal cysts. Nuclear octreotide scintigraphy was completely negative. Figure 2. [frontiersin.org]

Disseminated Cryptococcosis

A computed tomography scan showed multiple pulmonary nodules randomly distributed. [ncbi.nlm.nih.gov]

nodules peribronchovascular consolidation The most common CT findings in immunocompetent patients with pulmonary cryptococcosis are pulmonary nodules. [radiopaedia.org]

CT In general, there are several CT patterns that can be seen: clustered nodular pattern: most prevalent 4 solitary pulmonary nodule or mass with or without cavitation scattered [radiopaedia.org]

Drug-Induced Pulmonary Fibrosis

Pleural thickening and/or effusion, and multiple pulmonary nodules in the upper lobes secondary to iodine accumulation in type II pneumocytes has been described. [jtd.amegroups.com]

pulmonary nodules, [22] which may mimic metastatic disease [23] but have the histologic characteristic of COP. [emedicine.medscape.com]

Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of the literature. Am J Hematol 2002 ; 70 : 241 –245. 38. [annonc.oxfordjournals.org]

Pyopneumothorax

Source MeSH Aged Arthritis, Rheumatoid Asbestosis Diagnosis, Differential Empyema, Pleural Humans Male Multiple Pulmonary Nodules Pneumothorax Pub Type(s) Case Reports Journal [unboundmedicine.com]

Our patient at the time of presentation had multiple bilateral pulmonary nodules with right sided pleural effusion. [annsaudimed.net]

A 49-year-old male patient, an active case of sero positive rheumatoid arthritis involving multiple joints with bilateral necrobiotic pulmonary nodules is presented. [ncbi.nlm.nih.gov]

Disseminated Infection with Mycobacterium Avium Complex

Chest computed tomography scan showed multiple pulmonary nodules and a large cavity in the left upper lobe (segment 3a). [ncbi.nlm.nih.gov]

well-circumscribed pulmonary nodules, some of which had cavities; and granular shadows throughout the lungs. [doi.org]

Case reports for atypical presentations such as pulmonary nodules, pleurisy, multiple cavitary nodules and pleural effusion with hydropneumothorax have been published. [ncbi.nlm.nih.gov]

Pulmonary Sarcoidosis

Results of radiographs and a computed tomography scan of the chest revealed multiple pulmonary nodules with mediastinal and hilar adenopathy. [ncbi.nlm.nih.gov]

Pulmonary metastases from breast cancer are disseminated hematogenously, and the nodules are typically multiple, bilateral and peripheral in distribution. [cancerjournal.net]

A case of pulmonary sarcoidosis is presented characterized by multiple coalescent nodules and peripheral ground glass halos, which were fully reversible under repeat systemic [ncbi.nlm.nih.gov]

Pulmonary Plasma Cell Granuloma

Conclusion This case should alert the physician to consider PCG in the differential diagnosis of single or multiple pulmonary nodules in a child receiving immunosuppressive [ispub.com]

Pulmonary vasculitis, especially Wegener granulomatosis, may present with nodular pulmonary disease with or without constitutional symptoms. [clinicaladvisor.com]

Pulmonary Hemangioma

MeSH Descriptor Source: MeSH 2019 deskriptory Main Heading mnohočetné plicní uzly English Heading Multiple Pulmonary Nodules See (Czech) mnohočetné plicní noduly [cze0037457 [medvik.cz]

While all of these conditions tend to present as multiple pulmonary nodules, specific clinical and histologic features may help in distinguishing these tumors: Kaposi sarcoma [path.upmc.edu]

[…] sclerosing pneumocytoma, a rare tumor of the lung. ( 30847275 ) Yalcin B...Bolukbas O 2019 4 Pulmonary sclerosing pneumocytoma presenting as slow-growing multiple nodules [malacards.org]

Myopericytoma

Xiao-lian Song, Xin-ying Sun, Guo-liang Zhang, Yong-wei Yu and Chang-hui Wang, Myopericytoma Presenting As Multiple Pulmonary Nodules, Internal Medicine, 51, 6, (639), (2012 [doi.org]

Myopericytoma presenting as multiple pulmonary nodules. Intern. Med. 2012; 51 :639–642. [ PubMed ] [ Google Scholar ] 13. Zhang Z., Yu D., Shi H., Xie D. [ncbi.nlm.nih.gov]

Song XL, Sun XY, Zhang GL, et al: Myopericytoma presenting as multiple pulmonary nodules. Intern Med 2012;51:639-642. [karger.com]

Leiomyoma

Most occurrences are asymptomatic, and it presents as an incidental finding of well-defined multiple pulmonary nodules of varying sizes, 2 70% bilateral, and 17% unilateral [archbronconeumol.org]

Chinese-German Journal of Clinical Oncology. 2012; 11(1): 52-54 [Pubmed] 4 Multiple, Small Bilateral Pulmonary Nodules on Thoracic CT in a Patient With Chronic Cough Keith [ijpmonline.org]

Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. [journals.plos.org]