Presentation
Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo Evidence Literature Reference PMID: 17460053 Authors Jones MS, Lukashov VV, Ganac RD, Schnurr DP Title Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting [genome.jp]
[…] id=10.1371/journal.ppat.1000416 Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin http://jcm.asm.org/content/45/7/2144.short Frequent detection of highly diverse variants of cardiovirus [virologydownunder.com]
Here we present the isolation and characterization of a genotype 2 human cardiovirus (HTCV-UC6). Notably, successful cultivation of HTCV-UC6 from stool required the addition of cytokine-blocking antibodies to interrupt downstream antiviral pathways. [derisilab.ucsf.edu]
Structures resembling puff B are not present in enteroviruses (Fig. 1B and C) (33, 63). [jvi.asm.org]
Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin. J Clin Microbiol. 2007;45:2144–50. DOIPubMed Abed Y, Boivin G. New Saffold cardioviruses in 3 children, Canada. [wwwnc.cdc.gov]
Entire Body System
- Fever
Catarrhini; Hominoidea; Hominidae; Homininae; Homo Evidence Literature Reference PMID: 17460053 Authors Jones MS, Lukashov VV, Ganac RD, Schnurr DP Title Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever [genome.jp]
But in 2007 the genome of Saffold virus (SAFV-1) was deduced from a stool specimen of a human infant with fever[2]. [virologydownunder.com]
Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin. J Clin Microbiol. 2007;45:2144–50. DOIPubMed Abed Y, Boivin G. New Saffold cardioviruses in 3 children, Canada. [wwwnc.cdc.gov]
SAFV-1 has initially been isolated from a fecal specimen of an 8-month-old girl with fever of unknown origin [1]. [journals.plos.org]
SAFV-1 was identified in a stool sample of an infant with fever (4), and SAFV-3 was isolated from the cerebrospinal fluid of a patient with aseptic meningitis (5, 6). [jvi.asm.org]
- Fever of Unknown Origin
[…] of unknown origin. [genome.jp]
[…] id=10.1371/journal.ppat.1000416 Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin http://jcm.asm.org/content/45/7/2144.short Frequent detection of highly diverse variants of cardiovirus [virologydownunder.com]
Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin. J Clin Microbiol. 2007;45:2144–50. DOIPubMed Abed Y, Boivin G. New Saffold cardioviruses in 3 children, Canada. [wwwnc.cdc.gov]
SAFV-1 has initially been isolated from a fecal specimen of an 8-month-old girl with fever of unknown origin [1]. [journals.plos.org]
- Chronic Infection
This could support the notion of a longer than previously anticipated persistence of SAFV nucleic acids in the respiratory tract and possibly a chronic infection. [journals.plos.org]
Respiratoric
- Aspiration
SAFV-2 was the sole virus identified in nasopharyngeal aspirates from children with fever, otitis media or pneumonia.[6] SAFV-2 grows better in LLC-MK2 cells[6] suggesting variation in tropism compared to SAFV-1, possibly related to receptor usage. [virologydownunder.com]
In another study from Bejing including 1,558 children, SAFV was detected in 0.6% of nasopharyngeal aspirates from 506 patients with upper respiratory tract infection and in 0.4% of 1,032 patients with lower respiratory tract infections [29]. [journals.plos.org]
The medium was aspirated from the plates, and the cells were washed with 5 ml of serum-free MEM. [jvi.asm.org]
Neurologic
- Meningism
Serotyping from feces classified this virus as echovirus type 30, known to cause aseptic meningitis. [wwwnc.cdc.gov]
We address this gap in our current knowledge by studying the uncoating of the nonenveloped human cardiovirus Saffold virus 3 (SAFV-3) of the family Picornaviridae SAFVs cause diseases ranging from gastrointestinal disorders to meningitis ... [rcsb.org]
SAFVs cause diseases ranging from gastrointestinal disorders to meningitis. [jvi.asm.org]
Additionally, the virus was found in feces from Asian children with non-polio acute flaccid paralysis [9] and in cerebrospinal fluid specimens of patients with aseptic meningitis [12, 20–21]. [journals.plos.org]
Workup
Microbiology
- Pseudomonas
Evaluation of concentration efficiency of the Pseudomonas aeruginosa phage PP7 in various water matrixes by different methods. [link.springer.com]
Treatment
The correlation between ACE inhibitor treatment and increased expression of ACE2 led to the rumour that treatment with these drugs worsens infection and mortality. [lifeapps.io]
Occurrence and genetic diversity of human cosavirus in influent and effluent of wastewater treatment plants in Arizona, United States. [link.springer.com]
(B) Effect of DTT treatment on infectivity of SAFV-3 and EV71. Fractions of dead cells were determined based on propidium iodide staining. [jvi.asm.org]
Etiology
The third cohort comprised 348 specimens from hospitalized children with clinical meningitis or encephalitis in which no etiologic agent had been found; the specimens were sent for virologic investigation to the Institute for Hygiene and the Environment [wwwnc.cdc.gov]
Epidemiology
This comprehensive review highlights and discusses recent developments in epidemiology, human pathogenicity, animal, and molecular studies related to SAFV. It also provides detailed insights into the neuropathogenicity of SAFV. [onlinelibrary.wiley.com]
There are now at least eleven genotypes of human cardioviruses identified, and this is increasing [3, 4] but epidemiology for all cardioviruses is patchy. [virologydownunder.com]
Myocardium specimens were collected during 2010 at the UBMC Institute for Forensic Medicine from 10 epidemiologically unlinked children who died of SIDS. [wwwnc.cdc.gov]
Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan. [link.springer.com]
Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan. J Clin Virol 2015;70:7–13. pmid:26305811 View Article PubMed/NCBI Google Scholar 5. Tan SZ, Tan MZ and Prabakaran M. [journals.plos.org]
Pathophysiology
The true clinical significance and pathophysiology of SAFV thus has to be elucidated. [journals.plos.org]
Prevention
Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. [wwwnc.cdc.gov]
Thus, it is unlikely that pocket binding inhibitors that can prevent genome release from enteroviruses (64, 65) could be used to inhibit SAFV infections. Open in new tab Download powerpoint FIG 2 VP1 of SAFV-3 does not contain a hydrophobic pocket. [jvi.asm.org]