Presentation
Our patient presented to us on Day 21 of life though his symptoms had started by Day 12 of life. [dodleysevere.com]
Symptoms and Signs The clinical presentation of neonatal tuberculosis is nonspecific but is usually marked by multiple organ involvement. [merckmanuals.com]
Disseminated congenital tuberculosis presenting as peritonitis. Jpn J Radiol 2013; 31: 282-5. doi: 10.1007/s11604-012-0174-4. [ Links ] 52.- Hageman J, Shulman S, Schreiber M, Luck S, Yogev R. [scielo.cl]
Tuberculosis: Ancient Enemy Present Threat, "I must die": Tuberculosis in History. NAIAD [On-line information]. Available online at http://www.niaid.nih.gov/newsroom/focuson/tb02/story.htm. Tuberculosis (TB). [labtestsonline.it]
Gastrointestinal
- Failure to Thrive
The neonate may look acutely or chronically ill and may have fever, lethargy, respiratory distress or non-responsive pneumonia, hepatosplenomegaly, or failure to thrive. [merckmanuals.com]
Liver, Gall & Pancreas
- Hepatomegaly
The common presenting signs are respiratory distress (77%), hepatic and/or splenic enlargement.6 Our patient also had respiratory distress with hepatomegaly and elevated liver transaminases. [dodleysevere.com]
Treatment
Treatment is with isoniazid and other antituberculous drugs. [merckmanuals.com]
[…] of Latent TB: http://www.cdc.gov/tb/publications/factsheets/treatment/treatmentLTBI.htm Treatment of Drug-Susceptible Tuberculosis Disease in Persons Not Infected with HIV: http://www.cdc.gov/tb/publications/factsheets/treatment/treatmentHIVnegative.htm [labtestsonline.it]
[…] along with streptomycin and kanamycin for 9 to 12 months.4,7 For treatment of early onset DR-TB, the treatment remains challenging. [dodleysevere.com]
Perinatal tuberculosis: New challenges in the diagnosis and treatment of tuberculosis in infants and the newborn. [scielo.cl]
Epidemiology
Congenital tuberculosis in a neonatal intensive care unit: case report, epidemiological investigation, and management of exposures. [scielo.cl]
Prevention
Centers for Disease Control and Prevention. (2014 February 7, Updated.) Treatment for Latent TB Infection. Available online at http://www.cdc.gov/tb/topic/treatment/ltbi.htm. Accessed January 2016. Centers for Disease Control and Prevention. [labtestsonline.it]
Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases. [scielo.cl]