Presentation
Participant was a 70-yearold female patient, single; she presented progressive memory loss of an immediate verbal nature. [repository.ucc.edu.co]
Abstract Atypical Parkinson syndromes are a heterogeneous group of neurodegenerative diseases which present with parkinsonism and other non-motor symptoms. [ncbi.nlm.nih.gov]
Alzheimer’s disease and corticobasal degeneration presenting as corticobasal syndrome. Mov Disord. 2009; 24 (9) 1375-1379 26 Josephs K A, Whitwell J L, Boeve B F et al. [thieme-connect.com]
«Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome». Mov Disord (núm. 20, págs. 982-288). Williams, D. R.; Lees, A. J. (2009). [cv.uoc.edu]
Kompoliti K, Goetz CG, Boeve BF et al. (1998) Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 55: 957–961 PubMed CrossRef 34. [springermedizin.de]
Entire Body System
- Impaired Balance
Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). [ninds.nih.gov]
- Sepsis
Death is generally caused by pneumonia or other complications of severe debility such as sepsis or pulmonary embolism. Clinical Trials Clinical Trials [ninds.nih.gov]
Respiratoric
- Pneumonia
Death is generally caused by pneumonia or other complications of severe debility such as sepsis or pulmonary embolism. Clinical Trials Clinical Trials [ninds.nih.gov]
Psychiatrical
- Delusion
Delusions and Hallucinations in Alzheimer’s Disease: Review of the Brain Decade. Psychosomatics. 2003; 44 388-401 18 Girard C, Simard M. Clinical characterization of late- and very late-onset first psychotic episode in psychiatric inpatients. [thieme-connect.com]
Neurologic
- Myoclonus
Clonazepam may help the myoclonus. Occupational, physical, and speech therapy can help in managing disability. Read More Read Less Prognosis Prognosis Corticobasal degeneration usually progresses slowly over the course of 6 to 8 years. [ninds.nih.gov]
«Cognition and psychopathology in myoclonus-dystonia». Journal of Neurology, Neurosurgery and Psychiatry (núm. 83, págs. 814-820). Wenzel, T.; Schnider, P.; Wimmer, A.; Steinhoff, N.; Moraru, E.; Auff, E. (1998). [cv.uoc.edu]
Salazar G, Valls-Sole J, Marti MJ et al. (2000) Postural and action myoclonus in patients with parkinsonian type multiple system atrophy. Mov Disord 15: 77–83 PubMed CrossRef 60. [springermedizin.de]
- Akinesia
Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). [ninds.nih.gov]
- Insomnia
The patient presented conciliation insomnia, gait disturbances, and severe neurocognitive deficit, especially in executive functions, immediate verbal memory, and visuospatial functioning. [repository.ucc.edu.co]
Treatment
Read More Read Less Treatment Treatment There is no treatment available to slow the course of corticobasal degeneration, and the symptoms of the disease are generally resistant to therapy. [ninds.nih.gov]
Treatments which inhibit pathological protein aggregation and its spreading were developed and showed promising results in animal models. [ncbi.nlm.nih.gov]
Althaus A, Becker OA, Spottke A et al. (2008) Frequency and treatment of depressive symptoms in a Parkinson’s disease registry. Parkinsonism Relat Disord (in press) 4. [springermedizin.de]
Treatment Avenues for the Juvenile and Adult Onset Mitochondriopathies Alpers Syndrome, Ataxia Neuropathy Spectrum, MEMSA and PEO Caused by Polymerase-Gamma Mutations Ala467Thr and Trp748Ser. SM J Neurol Neurosci. 2017; 3(2): 1013. Review. [humangenetik.uk-koeln.de]
«Cognitive processes in idiopathic dystonia treated with high-dose anticholinergic therapy: implications for treatment strategies». Clinical Neuropharmacology (núm. 14, págs. 62-77). [cv.uoc.edu]
Prognosis
Read More Read Less Prognosis Prognosis Corticobasal degeneration usually progresses slowly over the course of 6 to 8 years. Death is generally caused by pneumonia or other complications of severe debility such as sepsis or pulmonary embolism. [ninds.nih.gov]
Watanabe H, Saito Y, Terao S et al. (2002) Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain 125: 1070–1083 PubMed CrossRef 80. [springermedizin.de]
«Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients». Brain (núm. 125, págs. 1070-1083). Wenning, G. K.; Ben-Shlomo, Y.; Magalhaes, M.; Daniel, S. E.; Quinn, N. P. (1994). [cv.uoc.edu]
Etiology
Hoglinger GU, Michel PP, Champy P et al. (2005) Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord 20: 118–119 PubMed CrossRef 27. [springermedizin.de]
Epidemiology
Epidemiologic aspects. Adv Neurol. 2000; 82 53-59 2 Wadia P M, Lang A E. The many faces of corticobasal degeneration. Parkinsonism Relat Disord. 2007; 13 (Suppl 3) S336-S340 3 Bartel C. Demenz bei degenerativen Systemerkrankungen. [thieme-connect.com]
Epidemiological Study of Dystonia in Europe (ESDE) (2000). «A prevalence study of primary dystonia in eight European countries». Journal of Neurology (vol. 10, núm. 247, págs. 787-792). [cv.uoc.edu]
Pathophysiology
«The pathophysiology of primary dystonia». Brain (núm. 121, págs. 1195-1212). Bihari, K.; Hill, J. L.; Murphy, D. L. (1992). «Obsessive-compulsive characteristics in patients with idiopathic spasmodic torticollis». [cv.uoc.edu]
Prevention
The goals of these studies are to increase scientific understanding of these disorders and to find ways to prevent, treat, and cure them. [ninds.nih.gov]