Presentation
Solitary piloleiomyomas tend to present on the lower extremity, while multiple piloleiomyomas frequently present on the extensor surface of extremities and trunk. [ncbi.nlm.nih.gov]
Entire Body System
- Asymptomatic
2005;11:21) Possibly botulinum toxin type A (Dermatology 2009;218:44) Possibly excision with dermal skin template for multiple tumors, carbon dioxide laser ablation (J Cutan Med Surg 2009;13:102) Clinical images Images hosted on other servers: Multiple asymptomatic [pathologyoutlines.com]
Observation in asymptomatic patients is a reasonable alternative. All patients need follow up because these lesions can grow and compress adjacent structure. [ncbi.nlm.nih.gov]
Cardiovascular
- Hypertension
[…] phenomenon, vasculitis, aneurysms, veins pathology, lymphatic vessels pathology, benign tumors of blood vessels, tumors of lymphatic system. 2.c The heart: congenital heart diseases, myocardial hypertrophy and heart failure, ischemic heart disease, hypertensive [departamentmorfologie.ro]
Skin
- Keratosis
[…] neoplasms of the pineal gland. 2.m The skin pathology: diseases of the epidermis, diseases of the basement membrane zone, scleroderma, skin sarcoidosis, infections of the skin, primary neoplasms of the skin: benign nevus, atypical nevus, malignant melanoma, keratosis [departamentmorfologie.ro]
- Ulcer
[…] gastrointestinal tract: congenital disorders of the esophagus, motor disorders of the esophagus, hiatal hernia, esophagitis, Barrett’s esophagus, esophageal varices, neoplasms of the esophagus, congenital disorders of the stomach, gastritis, peptic ulcer [departamentmorfologie.ro]
- Skin Lesion
[…] tumor, and eccrine spiradenomas which are part of the painful skin lesion differential. [ncbi.nlm.nih.gov]
Workup
Additional workup beyond biopsy is generally not indicated for genital leiomyomas or angioleiomyomas. [ncbi.nlm.nih.gov]
Treatment
Treatment / Management Effective treatment of symptomatic piloleiomyomas is often frustrating for both the physician and the patient due to a high rate of recurrence after surgical intervention and lack of successful pharmacological treatment options. [ncbi.nlm.nih.gov]
Genet Cytogenet 2008;183:83) Case reports 51 year old woman with multiple cutaneous and uterine leiomyomatosis (Dermatol Online J 2005;11:21) 79 year old man with hereditary leiomyomatosis and renal cell carcinoma syndrome (Dermatol Online J 2008;14:16) Treatment [pathologyoutlines.com]
[…] change (proliferative and non – proliferative, sclerosisng adenosis), fibroadenoma, intraductal papillomas, carcinoma of the breast, (hereditary factors, non-hereditary factors, carcinoma in situ, invasive carcinoma, metastases, prognostic factors, treatment [departamentmorfologie.ro]
Etiology
In addition, both the piloleiomyomas and genital leiomyomas may be problematic due to pain or discomfort.[1][2][3] Etiology Piloleiomyomas can develop sporadically or present as part of an autosomal dominant genetic syndrome. [ncbi.nlm.nih.gov]
Epidemiology
[…] grading and staging of metastasis, the clonal origin of cancer, the growth of cancers, the molecular genetics of cancers, viruses and human cencer, chemical carcinogenesis, physical carcinogenesis, tumor immunology, systemic effects of cancer on the host, epidemiology [departamentmorfologie.ro]
Epidemiology Data regarding the prevalence and incidence of cutaneous leiomyomas is limited. [ncbi.nlm.nih.gov]
Pathophysiology
Pathophysiology The pathophysiology of the three variants of cutaneous leiomyomas remains elusive, but as previously mentioned, underlying fumarate hydratase mutations are likely driving the development of multiple cutaneous piloleiomyomas in HLRCC (Reed [ncbi.nlm.nih.gov]