Presentation
Status in Israel Presentation and Status in Health Basket Presentation Basket Yarpa Pharmasoft Gel 30 g 12878 6357 Gel 100 g 89740 6423 Dosage Adults and children: Apply 2 to 4 times per day on the areas to be treated in a thin layer and massage lightly [medic.co.il]
As well as sedation, overdose often presents with anticholinergic symptoms (see Anticholinergic Syndrome). [rch.org.au]
Because of slowed GI motility, gut decontamination procedures may be helpful, even in late-presenting patients. Enhanced elimination. [accessmedicine.mhmedical.com]
The neuter βιβλίον biblíon "book" is a diminutive of βίβλος bíblos "book", named after the Phoenician port city of Byblos, also called Gibello, Gibelletto or Jebail, 30 km from present-day Beirut. [bibleous.com]
License number 133-24-24020 Presentation 30 g Fenistil gel packed in an aluminum tube sealed with a polypropylene cap. 100 g Fenistil gel packed in an aluminum tube sealed with a polypropylene cap. Not all pack sizes may be marketed. [myhealthbox.eu]
Entire Body System
- Hyperthermia
Treat coma (See Coma and stupor), seizures (See Seizures), hyperthermia (See Hyperthermia), and atypical ventricular tachycardia (See Circulation) if they occur. Monitor the patient for at least 6–8 hours after ingestion. [accessmedicine.mhmedical.com]
- Weakness
[…] promiscuity High CYP Inhibitory Promiscuity 0.5637 Ames test Non AMES toxic 0.5454 Carcinogenicity Non-carcinogens 0.9431 Biodegradation Not ready biodegradable 0.9888 Rat acute toxicity 2.7060 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak [go.drugbank.com]
Respiratoric
- Nasal Congestion
Associated Conditions Acute Sinusitis Allergic Reaction Anaphylaxis Anaphylaxis caused by Anaesthesia therapy Chronic Rhinitis Chronic Sinusitis Middle ear inflammation Nasal Congestion Rhinitis Rhinorrhoea Sinusitis Acute Rhinitis Contraindications & [go.drugbank.com]
The anticholinergic adverse effects of sedating H1-antihistamines, which include dry mucus membranes, might seem to improve nasal congestion.15 However, critical analysis of well-designed studies shows a lack of evidence for their use in children with [ncbi.nlm.nih.gov]
Skin
- Urticaria
In patients with wheals or swelling of the skin and/or mucosa, the history may be indicative of chronic spontaneous urticaria or hereditary angioedema. [onlinelibrary.wiley.com]
Indications Urticaria, pruritus, dermatoses, burns, insect bites, allergic dermatitis and eczema. Contra-Indications The product should not be used in case of hypersensitivity to dimethindene maleate or to one of the excipients. [medic.co.il]
Indications/Possible uses Urticaria, pruritus, dermatoses, burns, insect bites, allergic dermatitis and eczema. [myhealthbox.eu]
[…] cardiovascular, H1-antihistamines, QT prolongation Today the H-1antihistamines (H1A) are among the most widely used drugs worldwide to treat various allergic diseases, for which its effectiveness has been proven, such as allergic rhinitis, conjunctivitis and urticaria [medcraveonline.com]
Small Molecule Groups Approved, Investigational Structure Weight Average: 292.418 Monoisotopic: 292.193948778 Chemical Formula C20H24N2 Synonyms Dimethindene Dimetindene Dimetindeno Indication Indicated as symptomatic treatment of allergic reactions: urticaria [go.drugbank.com]
- Pruritus
Indications/Possible uses Urticaria, pruritus, dermatoses, burns, insect bites, allergic dermatitis and eczema. [myhealthbox.eu]
Indications Urticaria, pruritus, dermatoses, burns, insect bites, allergic dermatitis and eczema. Contra-Indications The product should not be used in case of hypersensitivity to dimethindene maleate or to one of the excipients. [medic.co.il]
[…] of various origins, except pruritus due to cholestasis; insect bites. [go.drugbank.com]
- Skin Lesion
Classification of anaphylaxis according to Ring and Messmer 5 Stage Symptoms I Skin lesions and/or slight increase in body temperature II Detectable, but not life-threatening cardiovascular reactions (tachycardia, hypotension) III Shock, life-threatening [onlinelibrary.wiley.com]
- Skin Disease
Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin. [go.drugbank.com]
Psychiatrical
- Anxiety Disorder
disorder/panic attack ▸ Somatoform disorder ▸ Stroke ▸ Intoxication with opiates/thanol Endocrinologic system ▸ Hypoglycemia ▸ Thyrotoxic crisis ▸ Pheochromocytoma ▸ Carcinoids Above all, it is the acute onset of symptoms that points to an anaphylactic [onlinelibrary.wiley.com]
Neurologic
- Insomnia
Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013;17:263-272. [PubMed] [Google Scholar] 4. [ncbi.nlm.nih.gov]
Hernandez LM, Wen J, Wang H, Hoare SR, Petroski RE, Jalali K, Yang C, Sacaan A, Madan A, Crowe PD, Beaton G: Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia [go.drugbank.com]
- Irritability
Benzalkonium chloride: irritant and can cause skin reactions. Avoid applying over large areas, especially in infants and young children. Avoid prolonged exposure to the sun of the areas treated. [medic.co.il]
Fenistil Gel is effective against pruritus of various origins and quickly soothes itching and irritation. The gel base facilitates penetration of the active substance through the skin. [myhealthbox.eu]
- Confusion
Calculate the maximum possible dose per kg Co-ingestants eg paracetamol Examination: CNS depression or confusion/delirium. [rch.org.au]
- Agitation
In overdose symptoms can include dizziness, tachycardia, headache drowsiness or agitation. [rch.org.au]
Treatment
For 24 hour advice, contact the Victorian Poisons Information Centre on 13 11 26 Background Antihistamines are commonly recommended for the treatment of allergic symptoms. This guideline will only deal with H1 antagonists. [rch.org.au]
Once the diagnosis of anaphylaxis is made, stage-oriented treatment has to be implemented. [onlinelibrary.wiley.com]
Treatment Emergency and supportive measures Maintain an open airway and assist ventilation if necessary (See Airway and Breathing). [accessmedicine.mhmedical.com]
[Article] Horak F, Unkauf M, Beckers C, Mittermaier EM: Efficacy and tolerability of intranasally applied dimetindene maleate solution versus placebo in the treatment of seasonal allergic rhinitis. [go.drugbank.com]
Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci. 2019; 20:213. [PMC free article] [PubMed] [Google Scholar] 20. Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. [ncbi.nlm.nih.gov]
Epidemiology
More accurate epidemiologic data is not available, in part due to the lack of uniformly implemented ICD coding for anaphylaxis and the fact that not every allergic emergency is actually treated by a physician 3. [onlinelibrary.wiley.com]
Pathophysiology
Pathophysiology and classification of severity Anaphylaxis is defined as a mast cell-dependent reaction with acute onset and potentially fatal outcome 4. [onlinelibrary.wiley.com]
Prevention
[…] assessment should indicate that the child or young person is at low risk of further self harm in the discharge setting Discharge information and follow-up Accidental ingestion: Parent information sheet from Victorian Poisons Information centre on the prevention [rch.org.au]
In the next few years the perception of drug-induced cardiovascular toxicity might easily change because of the approval of safer drugs or refinements of techniques for predicting, managing, or preventing such toxicity. None. [medcraveonline.com]
Prevention Apart from the acute intervention, preventive measures should be established for patients following a severe allergic reaction. [onlinelibrary.wiley.com]