Presentation
Consequently, it seems necessary to better characterize hMPV infections in adult inpatients: presentation, course profile and risk factors for morbidity and mortality. [clinicaltrials.gov]
The under-2 patients more frequently presented cough, rhinitis, apnoea and difficulty breathing, with statistically significant differences found ( p 0.001); meanwhile those over 2 more frequently presented seizures and fever ( p = 0.005). [elsevier.es]
Children with respiratory infections frequently present to primary care. [ncbi.nlm.nih.gov]
Conclusion In summary, the present study characterized the recent prevalence, seasonality and genetic diversity of HMPV in a large outpatient population presented with ILI in Senegal between 2012 and 2016. [bmcinfectdis.biomedcentral.com]
We recommend that you include samples from each age group in your clinical studies and present the data stratified by age (e.g., less than 5, 6- 21, 22-59, and greater than 60 years old) in addition to the overall data summary table. 6.G.v Presentation [fda.gov]
Entire Body System
- Weakness
MPV is more likely to cause severe infections in people with underlying health problems, such as prematurity, lung diseases (including asthma and emphysema) and weak immune systems, or in people older than 65. [newpittsburghcourier.com]
It has since been found to cause severe acute respiratory infections all over the world in young children, the elderly, and people with weak defense systems (the immunocompromised). It accounts for 1 to 3% of all flu -like illnesses. [medicinenet.com]
- Pain
This response causes the classic symptoms of a "cold," including local pain, low-grade fever, cough, runny nose, headache and sore throat. [lung.org]
You can relieve your symptoms by: Taking pain or fever medications (note: never give aspirin to children) Using a room humidifier or taking a hot shower to help ease a sore throat and cough Drinking plenty of liquids to stay hydrated Staying home and [dhs.wisconsin.gov]
Maybe the flank pain was caused by the pneumonia. [annalsofintensivecare.springeropen.com]
Clinical Diagnosis Associated with HMPV The most frequent symptoms among all ILI cases positive for HMPV were cough (94%), sudden onset (92%), fever/shivers (88%) and muscle pain/headache (72%) ( Table 3 ). [journals.plos.org]
- Weight Loss
In children under the age of 1 year, lower body temperature and weight loss are also seen. How Serious Is hMPV? In general, hPMV is not serious. [lung.org]
- Malaise
The Influenza-like illness case definition is a sudden onset of symptoms with at least one of the following systemic symptoms: fever or feverishness, malaise, headache, myalgia and at least one of the following respiratory symptoms: cough, sore throat [journals.plos.org]
- Unconsciousness
[…] severe pneumonia, i.e. cough or difficulty in breathing plus any one or more of the following: lower chest wall indrawing (severe pneumonia), oxygen saturation of less than 90 % (finger tip pulse oximetry), inability to drink or breast feed, prostrate or unconscious [bmcinfectdis.biomedcentral.com]
Respiratoric
- Aspiration
Study design: Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI). Results: We identified HMPV in 8 of 142 (5.6%) clinical samples. [agritrop.cirad.fr]
We collected 380 nasopharyngeal swabs or aspirates from ILI patients during the winter seasons 2005-2008 and examined them for influenza viruses and hMPV by one-step real time RT-PCR and nested RT-PCR. [eurosurveillance.org]
Use IMAGEN Human metapneumovirus (hMPV) Kit as a rapid, sensitive and specific method for direct detection of hMPV in clinical samples such as nasopharyngeal aspirates. [thermofisher.com]
There were 20 patients in whom other germs were simultaneously isolated in the nasopharyngeal aspirate. [elsevier.es]
METHODS: Hospitalized children aged < 14 years with ARTIs were enrolled from April 2017 to March 2018; nasopharyngeal aspirates were collected and subjected to real-time polymerase chain reaction tests for HMPV. [pesquisa.bvsalud.org]
- Sore Throat
This response causes the classic symptoms of a "cold," including local pain, low-grade fever, cough, runny nose, headache and sore throat. [lung.org]
Symptoms may include: Runny nose Cough Sore throat Fever Shortness of breath Most people recover within about seven to 10 days. [dhs.wisconsin.gov]
These include pyrexia and moist cough (12), sore throat (6), myalgia (5) and lethargy (4). This clinical picture is not dissimilar to influenza in the elderly. [www1.health.gov.au]
Cough, sore throat, runny nose, and high fever are most common. Wheezing, difficulty breathing (dyspnea), pneumonia, bronchitis, bronchiolitis, conjunctivitis, and inflammation of the middle ear (otitis media) each occur in 10% or more of patients. [medicinenet.com]
Most persons with hMPV infection have mild symptoms including cough, runny nose or nasal congestion, sore throat and fever. [idph.state.il.us]
- Hoarseness
More severe illness, with wheezing, difficulty breathing, hoarseness, cough, pneumonia, and in adults, aggravation of asthma, also has been reported. [idph.state.il.us]
In adult, HMPV usually causes mild disease characterised by cough, hoarseness, runny nose and sputum production. [chp.gov.hk]
Recognizing hMPV Infants and young children infected with hMPV demonstrate signs and symptoms similar to RSV: cough, wheezing, myalgia, dyspnea, tachypnea, rhinorrhea, and pyrexia. 8 In adults, signs and symptoms include nasal congestion, cough, rhinorrhea, hoarseness [journals.lww.com]
- Tachypnea
Her lung examination findings are notable for tachypnea with retractions and diffuse wheezing. [pedsinreview.aappublications.org]
[…] is unknown. 1 Infected adults who are asymptomatic may be an underappreciated source of transmission. 1 Recognizing hMPV Infants and young children infected with hMPV demonstrate signs and symptoms similar to RSV: cough, wheezing, myalgia, dyspnea, tachypnea [journals.lww.com]
Wheezing, rales, tachypnea, and dyspnea were considered to be signs of lower respiratory tract infection. [nejm.org]
Because of progressive tachypnea and the suspicion of progressive sepsis, antibiotic therapy was switched to a third-generation cephalosporin and subsequently to meropenem the next day because of further clinical deterioration. [annalsofintensivecare.springeropen.com]
- Pharyngitis
Demographic Characteristics of Patients with Influenza like Illness in Senegal between 2012 and 2016 Full size table Among symptoms reported in patients, fever was the most common with 95% followed by cough (77.1%), rhinitis (43.1%), myalgia (16.2%), pharyngitis [bmcinfectdis.biomedcentral.com]
ARI was defined by the National German Working Group Influenza at the Robert Koch Institute as patients with Bronchitis or Pneumonia or acute Pharyngitis with or without fever. [journals.plos.org]
Rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by RT-PCR and electrospray ionization mass spectrometry. J Virol Methods 2011;173:60-6. [Crossref] [PubMed] Zhao J, Ragupathy V, Liu J, et al. [atm.amegroups.com]
Musculoskeletal
- Myalgia
These include pyrexia and moist cough (12), sore throat (6), myalgia (5) and lethargy (4). This clinical picture is not dissimilar to influenza in the elderly. [www1.health.gov.au]
In others an influenza-like illness may result, with fever, myalgia and vomiting. [ncbi.nlm.nih.gov]
[…] of contagiousness is unknown. 1 Infected adults who are asymptomatic may be an underappreciated source of transmission. 1 Recognizing hMPV Infants and young children infected with hMPV demonstrate signs and symptoms similar to RSV: cough, wheezing, myalgia [journals.lww.com]
Fever, cough, myalgia, and headache were the predominant clinical features associated with HMPV detection, which is in line with results from a study conducted in China [28]. [bmcinfectdis.biomedcentral.com]
The Influenza-like illness case definition is a sudden onset of symptoms with at least one of the following systemic symptoms: fever or feverishness, malaise, headache, myalgia and at least one of the following respiratory symptoms: cough, sore throat [journals.plos.org]
Neurologic
- Headache
This response causes the classic symptoms of a "cold," including local pain, low-grade fever, cough, runny nose, headache and sore throat. [lung.org]
Fever, cough, myalgia, and headache were the predominant clinical features associated with HMPV detection, which is in line with results from a study conducted in China [28]. [bmcinfectdis.biomedcentral.com]
Clinical Diagnosis Associated with HMPV The most frequent symptoms among all ILI cases positive for HMPV were cough (94%), sudden onset (92%), fever/shivers (88%) and muscle pain/headache (72%) ( Table 3 ). [journals.plos.org]
- Irritability
Potentially interfering substances include, but are not limited to, the following: blood, nasal secretions or mucus, and nasal and throat medications used to relieve congestion, nasal dryness, irritation, or asthma and allergy symptoms. [fda.gov]
Treatment
Palivizumab (monoclonal antibody to RSV) is not effective for treatment. [msdmanuals.com]
Supportive treatment for patients varies with the severity of the illness but generally treatment consists of fever reducers, antihistamines, breathing treatments and other means of providing comfort to the patient until the illness resolves. [idph.state.il.us]
To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. [mendeley.com]
Prognosis
The primary objective is to describe the prognosis. [clinicaltrials.gov]
In addition, the genetic profiling of putative virulence factors and antiviral resistance markers using molecular tools such as NGS might improve patient prognosis and increase the accuracy in predicting responses to therapeutic intervention. [atm.amegroups.com]
Etiology
Human bocaviruses: possible etiologic role in respiratory infection. J Clin Virol 2015; 72: 75-81 28 Daleno C, Greenberg D, Piralla A. [thieme-connect.de]
Identification of etiologic agents and clinical characteristics for patients suspected of having pertussis in a large Children’s Hospital in China. Ann Transl Med 2019;7:443. [atm.amegroups.com]
Can respiratory syncytial virus etiology be diagnosed clinically? A hospital-based case-control study in children under two years of age. Eur J Epidemiol. 2003; 18 431-439 69 Wilkesmannn A, Schildgen O, Eis-Hübinger A. et al. [thieme-connect.com]
Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults. J Infect Dis. 2005; 192(7): 1149-1153. doi: 10.1086/444392. [medigraphic.com]
Viral etiology of acute respiratory infections among children in Porto Alegre, RS, Brazil. Rev Soc Bras Med Trop. 2002;35(4):283-91. [ Links ] 38. Escobar C, Luchsinger V, de Oliveira DB, Durigon E, Chnaiderman J, Avendaño LF. [scielo.br]
Epidemiology
Because human metapneumovirus is a newly recognized pathogen, many clinicians are unfamiliar with the epidemiology, pathogenesis, and clinical signs and symptoms of infection. [pedsinreview.aappublications.org]
Accueil Recherche Epidemiology and genotypic diversity of human metapneumovirus in paediatric patients with Epidemiology and genotypic diversity of human metapneumovirus in paediatric patients with acute respiratory infection in Beijing, China. [pesquisa.bvsalud.org]
Human metapneumovirus epidemiological and evolutionary patterns in coastal Kenya, 2007-11. BMC Infect Dis. 2016;16:301. [bmcinfectdis.biomedcentral.com]
Human metapneumovirus infection in Jordanian children: epidemiology and risk factors for severe disease. Pediatr Infect Dis J, 34 (2015), pp. 1335-1341 [9] J.V. Williams, S.J. Tollefson, P.W. Heymann, H.T. Carper, J. Patrie, J.E. Crowe. [elsevier.es]
Animal studies have been conducted but no human studies have been performed. 9 The CDC closely follows hMPV trending to assist with understanding the virus' infection burden and epidemiology. 1 Patient education While awaiting diagnosis and after the [journals.lww.com]
Prevention
Wang C; NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. [pesquisa.bvsalud.org]
Prevention and Treatment Currently, there is no specific antiviral therapy to treat HMPV and no vaccine to prevent HMPV. Medical care is supportive. [cdc.gov]
Prevention Vaccine is not available at the moment. [chp.gov.hk]
Schweon is an infection prevention consultant in Saylorsburg, Pa. The author has disclosed that he has no financial relationships related to this article. [journals.lww.com]
Prevention of hMPV infection There is no vaccine for available for hMPV. Prevention of hMPV infection depends on good hygienic methods to reduce the spread of the virus. Recommended Reading Falsey AR (October 2008). [quidel.com]