Presentation
In the present study, treatment of cultured endothelial cells with DL-homocysteine was specifically associated with a selective reduction in cellular binding sites for t-PA. [scienceopen.com]
Musculoskeletal
- Osteoporosis
The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin. Chem. Lab. Med. 2007; 45 :1621–32. [ PubMed ] [ Google Scholar ] 12. [ncbi.nlm.nih.gov]
It is associated with intellectual disability, osteoporosis, chest deformities, and increased risk of thrombotic episodes. [en.wikipedia.org]
Treatment
In conclusion, high-dose 5-MTHF treatment for 3 months ensures marked Hcy lowering to normal values even in subjects with high Hcy levels, and should be the treatment of choice in medium hyperhomocysteinemia. [insights.ovid.com]
"Homocysteine, folate and vitamin B12in neuropsychiatric diseases: Review and treatment recommendations". Expert Review of Neurotherapeutics. 9 (9): 1393–412. doi : 10.1586/ern.09.75. [en.wikipedia.org]
There is increasing evidence that time is necessary to identify the disorder and provide treatment for prevention. [scienceopen.com]
Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am. J. Med. 2005; 118 :1154–9. [ PubMed ] [ Google Scholar ] 41. Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler S, Allen RH. [ncbi.nlm.nih.gov]
Epidemiology
`Mendelian randomisation': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003 ; 32 : 1 -22. ↵ Smith GD, Ebrahim S. Mendelian randomisation: prospect, potential, and limitations. [bloodjournal.org]
Pathophysiology
"Pathophysiological consequences of homocysteine excess". The Journal of Nutrition. 136 (6 Suppl): 1741S–1749S. doi : 10.1093/jn/136.6.1741S. PMID 16702349. ^ McVeigh, Catherine; Passmore, Peter (September 2006). [en.wikipedia.org]
Prevention
[…] endothelial nitric oxide synthase, as increased endothelial lipid peroxidation and oxidation of the redox-sensitve dye 2,7-dichlorofluoresceine could only be observed after incubation of endothelial cells with L-, but not with D-homocysteine, and could be prevented [eurekaselect.com]
Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death: The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. J. Am. Med. [ncbi.nlm.nih.gov]
"Homocysteine-lowering interventions for preventing cardiovascular events". The Cochrane Database of Systematic Reviews. 1 : CD006612. doi : 10.1002/14651858.CD006612.pub4. ISSN 1469-493X. PMC 4164174. PMID 25590290. ^ Cattaneo, Marco (1999). [en.wikipedia.org]
There is increasing evidence that time is necessary to identify the disorder and provide treatment for prevention. [scienceopen.com]