Presentation
Entire Body System
- Congestive Heart Failure
Heart Failure 69 0.654 452 SCN049 Second-Degree Atrioventricular Block 34 0.651 453 IRN001 Iron Deficiency Anemia 58 0.651 454 MCL027 Macular Dystrophy, Dominant Cystoid 51 0.639 455 NTR005 Nutritional Deficiency Disease 60 0.639 456 P LYM033 Lymphoproliferative [malacards.org]
Cardiovascular
- Heart Failure
Deaminase Deficiency 59 3.355 43 NRR001 Neuroretinitis 42 3.324 44 RTN023 Retinitis 45 3.324 45 BRN071 Brain Injury 50 3.312 46 P MYC084 Mycobacterium Tuberculosis 1 68 3.292 47 LPP008 Lipoprotein Quantitative Trait Locus 65 3.279 48 c ACT071 Acute Kidney Failure [malacards.org]
Neurologic
- Tremor
60 0.981 351 P MYS005 Myositis 56 0.978 352 c PRC016 Pre-Eclampsia 64 0.973 353 P HYP061 Hypertrophic Cardiomyopathy 69 0.973 354 P EYD002 Eye Disease 57 0.970 355 BRN032 Brain Glioma 45 0.970 356 c BCT007 Bacterial Meningitis 55 0.947 357 P TRM003 Tremor [malacards.org]
Workup
Serum
- Hyperuricemia
Parkinsonism 55 3.245 50 ATR057 Atrioventricular Block 54 3.240 51 TRM010 Traumatic Brain Injury 50 3.234 52 TXC005 Toxic Shock Syndrome 62 3.220 53 P LNG032 Lung Cancer 98 3.159 54 MNT002 Mental Depression 56 3.136 55 CYS001 Cystic Fibrosis 77 3.125 56 HYP014 Hyperuricemia [malacards.org]
Treatment
Cited by 62 articles The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia. Lee JM, Shim YJ, Kim DH, Jung N, Ha JS. Lee JM, et al. [pubmed.ncbi.nlm.nih.gov]
Prevention
Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions 0.974 ENSG00000279624 annotation not available 0.970 GMPR GMP reductase 1; Catalyzes the irreversible [string-db.org]