Presentation
[…] on varying clinical presentation: progressive... [dermatologyadvisor.com]
Older lesions tend to be less inflammated and extravasated RBC may no longer be found present at the affected area. [sydneyskinandvein.com.au]
Histologically, PPD presents with perivascular infiltrates of lymphocytes and macrophages centered around the superficial small blood vessels with narrowing of the lumina. [mdedge.com]
Other forms are rare and with an unusual presentation [1]. 2. [mdpi.com]
Entire Body System
- Falling
He had an avid grasp of facts, a clear understanding and excellent memory, which assured him a distinguished student career and a successful and multi-faceted life which falls naturally into five main phases: England and Europe until the age of 28; followed [history.rcplondon.ac.uk]
The platelets fall below 50 000/mm3 and may even be absent. Secondary thrombocytopenia purpura. [drmhijazy.com]
- Hypothermia
Hypothermia in the newborn: a new syndrome? Lancet 1955; i: 613-14. Mann TP, Elliott RIK. Neonatal cold injury due to accidental exposure to the cold. Lancet 1957; i: 229-34. Gladston CL, Groncy P, Griffin JH. [drmhijazy.com]
Cardiovascular
- Venous Insufficiency
The symptoms of venous insufficiency include pain, soreness, burning, aching, throbbing, cramping, muscle fatigue, and “restless legs.” [patientcareonline.com]
Venous insufficiency likely plays a role in localization of this variant. Majocchi disease is associated with bluish-red annular macules and telangiectatic puncta; atrophy of the central area is also frequently identified. [dermatologyadvisor.com]
Venous insufficiency might play a role in their localization. Moreover, chronic alcohol uptake seems to be related to the development of purpura and Schamberg disease, especially when liver damage is associated [13]. 4.2. [mdpi.com]
Psychiatrical
- Withdrawn
Schamberg's disease treatment and management[5, 7] Any suspected precipitants should be withdrawn. Pruritis - treat with mild topical corticosteroid or antihistamines. Good results have been obtained with narrow-band ultraviolet light. [patient.info]
Workup
Serum
- Thrombocytosis
Platelet alteration could result from thrombocytopenic, thrombocytopatic, or thrombocytosis syndromes. These forms are usually associated with bleeding in other locations, or in case of thrombocytosis with a prothrombotic state. [mdpi.com]
Treatment
[…] and no standardized treatments with proven effectiveness exist, the risks and benefits of any treatment should be carefully weighed up. [actasdermo.org]
Oral therapies used for treatment of pigmented purpuric dermatosis. Table 3. Oral therapies used for treatment of pigmented purpuric dermatosis. [mdpi.com]
Pigmented purpuric lichenoid dermatitis of Gougerot and Blum - red/brown papules and plaques in men - which responds to psoralen combined with ultraviolet A (PUVA) treatment. [patient.info]
Treatments include topical corticosteroids and topical vitamin C. [patientcareonline.com]
Treatment Treatment comprises rapid transfusion of fresh frozen plasma. [drmhijazy.com]
Prognosis
Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27:504-528. Marks, JG, Miller JJ. Lookingbill and Marks’ Principles of Dermatology, 4th ed. [clinicaladvisor.com]
Etiology
Etiology In older children, purpura fulminans may have several causes. [drmhijazy.com]
The etiologies of these conditions of the pigmented purpuric dermatoses are unknown, but a common pathogenetic mechanism is suspected. [clinicaladvisor.com]
Testing for antinuclear antibodies, rheumatoid factor, anti-HBsAg antibody, and anti-hepatitis C virus antibody aids in excluding a rheumatologic or viral etiology. [dermatologyadvisor.com]
The etiology of PPD is unknown; however, important cofactors include venous hypertension, exercise and gravitational dependency, capillary fragility, focal infections, and chemical ingestions.1 Drugs are the most important provoking factors, including [mdedge.com]
The etiology of PPD remains unknown. However, past literature work has implicated a number of factors that may affect the appearance of the condition. These factors include venous hypertension, exercise and lower limbs dependence. [sydneyskinandvein.com.au]
Epidemiology
(Epidemiology) Schamberg's disease is rare and there are few epidemiological studies in the literature. Schamberg disease may affect all ages but commonly occurs in middle-aged to older men and less frequently in children[2]. [patient.info]
We report a case of GPPD and provide a thorough literature review focusing on epidemiology, clinical symptoms, and treatment.2-17 The eTable summarizes all reported cases of GPPD. [mdedge.com]
Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27:504-528. Marks, JG, Miller JJ. Lookingbill and Marks’ Principles of Dermatology, 4th ed. [clinicaladvisor.com]
Epidemiology of varicose veins. World J Surg. 1986;10:898-902. 4. McCausland AM, Holmes F, Trotter AD Jr. Venous distensibility during the menstrual cycle. Am J Obstet Gynecol. 1963;86:640-645. 5. Barwin BN, Roddie IC. [patientcareonline.com]
[…] lichenoid dermatosis of Gougerot and Blum, lichen aureus (lichen purpuricus), and Majocchi disease (purpura annularis telangiectodes).1 Less common variants are granulomatous PPD, itching purpura of Loewenthal, linear PPD, transitory PPD, and familial PPD.2 Epidemiology [actasdermo.org]
Pathophysiology
Article Menu Font Type: Arial Georgia Verdana Open AccessReview 1 Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy 2 Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 [mdpi.com]
Prevention
Other tried treatments include vitamin C supplements, laser therapy and wearing support hosiery to prevent venous stasis. There is no evidence of definite benefit of the former two. Immunosuppressants have also been used[6]. [patient.info]
Leg compression and avoiding long periods of standing are recommended to prevent associated venous stasis.1 Psoralen photochemotherapy has been shown to be successful in treating Schamberg disease, pigmented purpuric dermatosis of Gougerot-Blum, and lichen [dermatologyadvisor.com]
Treatment with colchicine dates back to the year 2000, which is low cost, effective yet prevents relapse but newer therapeutic modes with Advanced fluorescence technology (AFT) pulsed light therapy imparts favourable results, using a 570 mm handpiece [jdrntruhs.org]
Advise patients that treatment does not prevent the development of new spider telangiectases. References: REFERENCES:1. Robson A. The pathology of cutaneous T-cell lymphoma. Oncology (Williston Park). 2007;21(2, suppl 1):9-12. 2. [patientcareonline.com]