Presentation
The occurrence of congenital keratoconus posticus circumscriptus in two siblings presenting a previously unrecognized syndrome. Am J Ophthalmol. 1961 Jul;52:53-7. [disorders.eyes.arizona.edu]
Case presentation A 6-week old African-American male presented for an ophthalmologic evaluation for a right corneal opacity noted at birth by a neonatologist (Fig. 1). [docksci.com]
Case presentation A 6-week old African-American male presented for an ophthalmologic evaluation for a right corneal opacity noted at birth by a neonatologist (Fig. 1 ). [bmcophthalmol.biomedcentral.com]
The proband presented at age 28 years with a painful eye with severely reduced visual acuity. Anterior segment dysgenesis, microphthalmia, inferior iris coloboma, and iridocorneal adhesion with overlying corneal opacity were present. [findzebra.com]
Entire Body System
- Fever
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Respiratoric
- Cough
Spasms, pain, cough, itch, and other conditions. How does Bitter Almond work? Are there any interactions with medications? Dosing considerations for Bitter Almond. [link2uni.com]
Cardiovascular
- Mitral Valve Prolapse
valve prolapse Osteogenesis imperfecta 16. ASSOCIATED OCULAR DISORDES • Retinitis pigmentosa • Lebers congenital amaurosis • Blue sclerae • Congenital cataract • Aniridia • Retinopathy of prematurity • Fuchs dystrophy • Posterior polymorphous dystrophy [slideshare.net]
Skin
Eyes
- Aniridia
The condition may be associated with osteogenesis imperfecta, ectopia lentis, aniridia, retinitis pigmentosa, Down's syndrome, Ehlers-Danlos syndrome, Marfan's syndrome. [medical-dictionary.thefreedictionary.com]
ASSOCIATED OCULAR DISORDES • Retinitis pigmentosa • Lebers congenital amaurosis • Blue sclerae • Congenital cataract • Aniridia • Retinopathy of prematurity • Fuchs dystrophy • Posterior polymorphous dystrophy • Granular and lattice dystrophy ALLERGIC [slideshare.net]
- Prolapse
Osteogenesis imperfecta • Congenital hip dysplasia • Oculodento digital syndrome • Rieger’s syndrome Atopic dermatitis Down syndrome Ehlers-Danlos syndrome • Crouzon’s syndrome • Floppy eyelid syndrome • Down syndrome • Turners syndrome • Mitral valve prolapse [slideshare.net]
Treatment
Treatment Treatment Options: No treatment beyond surgical repair of the cleft lip and palate or scoliosis is available. Peripheral iridotomies have been done in the presence of shallow anterior chambers. [disorders.eyes.arizona.edu]
Treatment - Keratoconus posticus circumscriptus Not supplied. Resources - Keratoconus posticus circumscriptus Not supplied. [checkorphan.org]
"Keratoplasty for the Treatment of Keratoconus". Transactions of the American Ophthalmological Society. 46: 127–53. PMC 1312756. [en.wikipedia.org]
CPE - author's reply. ( 30818003 ) Lim YJ...Choi SH 2019 12 Comparative Analysis of blaKPC Expression in Tn4401 Transposons and the Tn3-Tn4401 Chimera. ( 30833426 ) Huang J...Ji J 2019 13 In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment [malacards.org]
A clinical trial may include existing medications or treatments in combination with new drugs or may involve a different approach to sequencing or dosing of medications and treatment (Dzolganovski, 2010). [link2uni.com]
Prognosis
Prognosis - Keratoconus posticus circumscriptus Not supplied. Treatment - Keratoconus posticus circumscriptus Not supplied. Resources - Keratoconus posticus circumscriptus Not supplied. [checkorphan.org]
Diagnosis and Prognosis: The diagnosis is based on a collaborative effort by ophthalmologists, pediatricians and orthopedists. No information on longevity is available but the combination of anomalies requires supportive care for patients. [disorders.eyes.arizona.edu]
[…] keratoconus and other corneal thinning conditions as removal of corneal stromal tissue will further damage an already thin and weak cornea.[71] For similar reasons, radial keratotomy has also generally not been used for people with keratoconus.[72][73] Prognosis [en.wikipedia.org]
Etiology
Genetics: The etiology of this condition is unknown but the rare familial cases reported suggest autosomal recessive inheritance. No gene mutation has been found. [disorders.eyes.arizona.edu]
[Current concepts of the etiology and pathogenesis of keratoconus]. Kasparova EA. Kasparova EA. Vestn Oftalmol. 2002 May-Jun;118(3):50-3. Vestn Oftalmol. 2002. PMID: 12226986 Review. Russian. No abstract available. [pubmed.ncbi.nlm.nih.gov]
The etiology and pathogenesis of the disease are unknown. [scielo.br]
ETIOLOGY : • Definite etiology is unknown. • 95% of patients do not show evidence of specific hereditary pattern. [slideshare.net]
Conclusion: AS-OCT is a useful tool in cases when a child presents with a corneal opacity of unknown or unclear etiology. In our patient, AS-OCT showed the classic description of central corneal thinning seen in this condition. [docksci.com]
Epidemiology
"A 48-year clinical and epidemiologic study of keratoconus". American Journal of Ophthalmology. 101 (3): 267–73. doi:10.1016/0002-9394(86)90817-2. PMID 3513592. ^ Weissman BA, Yeung KK. [en.wikipedia.org]
Pathophysiology
FOXO1, FNDC3B, IMMP2L and RXRA-COL5A1.[17] Others likely also exist.[17] Patients with a parent, sibling, or child who has keratoconus have 15 to 67 times higher risk in developing corneal ectasia compared to patients with no affected relatives.[7][8] Pathophysiology [en.wikipedia.org]
Prevention
Prevention - Keratoconus posticus circumscriptus Not supplied. Diagnosis - Keratoconus posticus circumscriptus signs and symptoms of Keratoconus posticus circumscriptus may vary on an individual basis for each patient. [checkorphan.org]
Hence, additional precautions to prevent vitreous loss and high IOP are recommended while planning cataract extraction in cases of keratoconus posticus circumscriptus. [ijo.in]
• After lifting the LASIK flap, the flap is folded over itself in order to prevent absorption of Riboflavin by the flap. • A single drop of Vibex Xtra is placed over the exposed stromal bed and carefully spread. 106. • Soaking of Riboflavin is continued [slideshare.net]