Presentation
[…] following insect bites has been described (Haematologica 2010;95:449) This may be related to homing of neoplastic cells to sites of inflammation Clinical features 70% present with stage III - IV disease (J Clin Exp Hematop 2017;57:120) Peripheral or [pathologyoutlines.com]
Aggressive NKcell leukémia Both cell subsets mediate «non-mhc» restricted cytotoxicity 26 Aggressive NK cell Leukemia/lymphoma 27 AGRESSIVE NK-CELL LEUK/LYMPHOMA Usually presents as disseminated disease with : - hepatosplenomegaly - constant systemic [docplayer.fr]
Respiratoric
- Aspiration
Large cells with pleomorphic nuclei Mitoses and apoptosis Intrasinusoidal infiltrate Intrasinusoidal infiltrate Focal infiltrate Hallmark cells Hallmark cells Polymorphous background CD3 CD3 CD30 ALK1 ALK1 ALK1 EMA Granzyme B CD45 Bone marrow aspirate [pathologyoutlines.com]
Treatment
N Engl J Med 329: 1608–1614 CrossRef PubMed CAS Google Scholar Czuczman MS, Grillo-Lopez AI, White CA et al. (1999) Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy [link.springer.com]
First line treatment is chemotherapy (CHOP with or without etoposide) (Curr Hematol Malig Rep 2018;13:135, Haematologica 2019;104:e562) Allogeneic stem cell transplant is useful in refractory cases (Lancet Oncol 2004;5:127) Brentuximab vedotin (anti-CD30 [pathologyoutlines.com]
Nat Rev Immunol, 2005 70 Non anaplastic T cell Lymphoma 120 Percent Survival p = B = 1595 T = Months from start of treatment 71 LYMPHOMES T et NK «MATURES» PRESENTATION GANGLIONNAIRE LYMPHOME T ANGIOIMMUNOBLASTIQUE LYMPHOME T PERIPHERIQUE, sans autre [docplayer.fr]
Prognosis
Blood 116: 2040–2045 CrossRef PubMed CAS Google Scholar Pfreundschuh M, Trumper L, Osterborg A et al. (2006) CHOP-like chemotherapy plus rituximab versus CHOP like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: [link.springer.com]
No prognostic difference between classic and variant translocations Small cell or lymphohistiocytic variant morphology often present with disseminated disease at diagnosis (J Clin Oncol 2011;29:4669) Circulating tumor cells are associated with poor prognosis [pathologyoutlines.com]
Etiology
Etiology is unknown; the anaplastic lymphoma receptor tyrosine kinase ALK gene (2p23) is overexpressed due to t(2;5)(p23;q35) translocation (Orphanet: Anaplastic Large Cell Lymphoma [Accessed 27 January 2020]) Cases with the NPM-ALK translocation show [pathologyoutlines.com]
Pathophysiology
Pathol 2008;39:1331) Central nervous system involvement is more commonly seen with bone marrow involvement and is a poor prognostic finding Occasional leukemic presentation in peripheral blood with the small cell variant (Br J Haematol 2014;165:545) Pathophysiology [pathologyoutlines.com]