Presentation
However, significant statistical heterogeneity was present (I2= 90%, P < 0.00001). 1.4 Quality of life Two studies (EMBRACA and OLYMPIAD) reported quality of life outcomes so this was not amenable to meta‐analysis. [cochranelibrary.com]
Entire Body System
- Anemia
Los efectos adversos más frecuentes informados en los cinco estudios fueron neutropenia, anemia y fatiga. [cochranelibrary.com]
- Fatigue
Common toxicities for all PARP inhibitors included fatigue, gastrointestinal toxicities and cytopenias (Ho 2019, Murthy 2019). [cochranelibrary.com]
Neurologic
- Headache
Also, use of single‐agent PARP inhibitors was associated with a significantly increased risk of anaemia and any grade of headache, but a reduced risk of neutropenia and any grade of palmar‐plantar erythrodysesthesia syndrome, as compared with chemotherapy [cochranelibrary.com]
Workup
Serum
- Neutropenia
Los efectos adversos más frecuentes informados en los cinco estudios fueron neutropenia, anemia y fatiga. [cochranelibrary.com]
Treatment
Types of interventions The intervention was the use of PARP inhibitors for locally advanced or metastatic breast cancer treatment. The comparator involved treatment with chemotherapy without PARP inhibitors. [cochranelibrary.com]
Prognosis
Expression of the ER and PR in tumours confers a better prognosis, while HER2‐positive and triple‐negative breast cancer (tumours without expression of ER/PR and HER2) tend to be indicative of a more aggressive cancer (Foulkes 2010). [cochranelibrary.com]