Presentation
Presenting symptoms depend on the region involved. [radiopaedia.org]
Case Report A 9-year-old girl presented with history of abdominal pain, prolonged diarrhea, and rectal bleeding. She presented cutaneous leishmaniasis at 3-year-old, diffuse verruca vulgaris, recurrent skin, and respiratory infections. [ncbi.nlm.nih.gov]
Clinical manifestations of colonic malacoplakia are non specificas well as endoscopic and radiologic presentations and can be mistaken for malignant tumor as it was the case in our patient. [latunisiemedicale.com]
The patient is clinically healthy until present (36 months) with normal laboratory indicators and CT find. The clinical symptoms of this very rare disease are different and depend upon the organ location. [pubmed.ncbi.nlm.nih.gov]
Respiratoric
- Aspiration
Similar articles Fine needle aspiration cytology of malacoplakia of the thyroid. A case report. Jeffrey PB, Chandrasoma P, Greaves T. Jeffrey PB, et al. Acta Cytol. 1996 Sep-Oct;40(5):970-4. doi: 10.1159/000334011. Acta Cytol. 1996. [pubmed.ncbi.nlm.nih.gov]
Gastrointestinal
- Abdominal Pain
Clinical manifestations of colonic malacoplakia are nonspecific; rectal bleeding, diarrhea, abdominal pain, and fever are the usual presenting symptoms [5, 9]. [ncbi.nlm.nih.gov]
Workup
The laboratory workup showed a normal leukocyte count at 9700/mm3 with hypereosinophilia at 1700/mm3. The haemoglobin and the platelet counts were normal. [ncbi.nlm.nih.gov]
Treatment
In cases of progressive lesion or no response to medical treatment, the surgical resection may be the other choice of treatment [4–6]. 4. [ncbi.nlm.nih.gov]
Treatment usually consists of antibiotics and surgical excision. [research.vumc.nl]
Treatment and prognosis Although malakoplakia may be extremely aggressive, invading the adjacent spaces and even causing bone destruction, non-surgical medical management is the mainstay of treatment. [radiopaedia.org]
Quinolone antibiotic treatment and surgical excision or incision and drainage lead to the highest cure rates (90% and 81%, respectively). [scienceopen.com]
Prognosis
Treatment and prognosis Although malakoplakia may be extremely aggressive, invading the adjacent spaces and even causing bone destruction, non-surgical medical management is the mainstay of treatment. [radiopaedia.org]
Etiology
[…] and later named by Von Hansseman "Malakoplakia" comes from Greek words malakos (soft) and plakos (plaque) Epidemiology More common in immunocompromised (HIV, renal transplant recipients) and women Mean age at diagnosis is fifth decade Rare in children Etiology [pathologyoutlines.com]
In our case, the patient presented with diabetesdesequilibration.The etiology of malacoplakia is still not fully understood, but there is an association with Gram-negative bacterial infections, particularly with Escherichia coli. [latunisiemedicale.com]
Epidemiology
[…] found Abstract : found Article : found Is Open Access Authors: 1, &, Salma Ouassour 1, Mokha Tazi 1, Adib Filali 1, Mohammad Alami 1 Publication date (Electronic): 09 September 2015 Journal: The Pan African Medical Journal Publisher: The African Field Epidemiology [scienceopen.com]
Single or multiple tumors Often misdiagnosed clinically as a malignant condition Terminology First described by Michaelis and Gutmann in 1902 and later named by Von Hansseman "Malakoplakia" comes from Greek words malakos (soft) and plakos (plaque) Epidemiology [pathologyoutlines.com]
J Urol 116(1):41–42 CAS PubMed Google Scholar Kantor AF, Hartge P, Hoover RN, Fraumeni Jr JF (1988) Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder. [link.springer.com]
Prevention
[…] intestinal epithelial cells A case of severe CMV-colitis in an HIV positive patient despite moderate immunodeficiency Cost-effective and safe ambulatory long-term immunoprophylaxis with intramuscular instead of intravenous hepatitis B immunoglobulin to prevent [asklepios.com]
Although the response to therapy is unpredictable, patients may respond if the treatment is continued on a long-term basis, in order to prevent the recurrence and the extension of diseases [6]. [ncbi.nlm.nih.gov]