Presentation
The material discussed in the Materials is not intended to present the only or necessarily the best pediatric method or procedure, but rather presents the approach or opinion of the discussant. [pediatriccare.solutions.aap.org]
Entire Body System
- Hypothermia
Toxicity In high doses or when ingested, naphazoline can lead to central nervous system depression (which can progress to coma and death), hypothermia, bradycardia, and death 1. This effect is especially pronounced in children under 6 years 1, 2. [drugbank.ca]
Toxicity In high doses or when ingested, naphazoline can lead to central nervous system depression (which can progress to coma and death), hypothermia, bradycardia, and death1. This effect is especially pronounced in children under 6 years1,2. [go.drugbank.com]
- Inflammation
Nafazolina La Santé should not be used if there is raised pressure inside the eyeball (glaucoma), damage to the corneas, inflammation of the iris (acute iritis) or any other serious eye disease. [pillintrip.com]
Respiratoric
- Rhinitis
N1 InChI 1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4) InChI key ZAHXYMFVNNUHCP-UHFFFAOYSA-N Description Application Therapeutic use to: • Combat ammonia poisoning • Treat seasonal allergy rhinitis [sigmaaldrich.com]
Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion. [en.wikipedia.org]
Eur J Pediatr. 1993 Nov;152(11):944-6. [ PubMed:8276031 ] Ramey JT, Bailen E, Lockey RF: Rhinitis medicamentosa. [drugbank.ca]
Long term use of naphazoline can lead to rhinitis medicamentosa once naphazoline is stopped3. This condition is a result of norepinephrine release by naphazoline triggering a negative feedback loop3. [go.drugbank.com]
- Nasal Congestion
Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion. [en.wikipedia.org]
In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion. [hmdb.ca]
Summary Naphazoline is a sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion. [go.drugbank.com]
[…] preparation for nasal congestion 1, 6, 7. [drugbank.ca]
Cardiovascular
- Hypotension
Hypertension may be followed by rebound hypotension. In addition, overdosage may cause increased redness of the eye. Treatment of side-effects is symptomatic. [pillintrip.com]
Neurologic
- Tremor
Side effects of Naphazoline may include: Central nervous system effects (anxiety, dizziness, tremor, etc.) [rxlist.com]
Treatment
Allergic Conjunctivitis (AC) 1 3 Completed Treatment Allergic Conjunctivitis (AC) 2 3 Completed Treatment Allergic Disorder of Respiratory System / Cold / Flu caused by Influenza 1 3 Completed Treatment Nasal Congestion 1 1 Not Yet Recruiting Treatment [go.drugbank.com]
[…] rely on their own discretion and judgment in medical diagnosis and treatment. [pediatriccare.solutions.aap.org]
Gene Name ADRA1A Uniprot ID P35348 Uniprot Name Alpha-1A adrenergic receptor Molecular Weight 51486.005 Da References Bogacka E: [Decongestants in treatment of nasal obstruction]. [drugbank.ca]
Treatment of side-effects is symptomatic. [pillintrip.com]
A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. [webmd.com]
Prevention
This will prevent the medication from draining away from the eye. Try not to blink and do not rub the eye. Repeat these steps if your dose is for more than 1 drop and for the other eye if so directed. Do not rinse the dropper. [webmd.com]
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