Presentation
He subsequently expired within one month of presentation. CONCLUSIONS We present a unique case of high-grade anterior mediastinum ESOS and a review of the literature regarding all documented cases of ESOS to date. [ncbi.nlm.nih.gov]
Clinical settings In the present study, cutaneous infection often occurred in elderly patients. [medicaljournals.se]
Entire Body System
- Lymphadenopathy
This report has emphasized the importance of a careful evaluation of the chest roentgenogram for lymphadenopathy in children with wheezing, cough, or other symptoms of lower airway disease. [ncbi.nlm.nih.gov]
Surgical excision is also frequently used to hasten resolution of localized lymphadenopathy and of solitary skin lesions, even though these lesions are likely to be self-limiting. [apps.who.int]
[…] cosmetic surgery) Musculoskeletal Pain, joint stiffness, fever, malaise, weight loss Spread of infection from contiguous source (e.g., surgery, injection, injury) Prosthetic joint surgery Joint injections Systemic (disseminated) Rash or other skin lesions, lymphadenopathy [cdc.gov]
Frontal chest radiograph shows bilateral bulky mediastinal lymphadenopathy. Clinical and imaging findings are consistent in showing immune reconstitution syndrome. [ajronline.org]
Lymphadenopathy, particularly cervical lymphadenopathy, can be a manifestation of SGM disease. Cutaneous lesions can be a result of focal infection due to a puncture in the skin or after an invasive procedure. [infectiousdiseaseadvisor.com]
- Disability
They are shielded by an unusually thick cell wall, can ‘hide’ inside other cells or within biofilms where they cannot be reached by antibiotics and disinfectants, can grow under nutrient- and oxygen-poor conditions and thrive at temperatures that would disable [pharmaphorum.com]
NTM disable the defenses of macrophages, allowing the bacteria to multiply inside the body. Common NTM lung disease symptoms which include coughing, shortness of breath and fatigue can worsen over time. And if not treated, can cause lung damage. [aboutntm.com]
When neglected lesions heal, scarring may cause restricted movement of limbs and permanent disabilities. The diagnosis can be confirmed by PCR and culture. [healio.com]
- High Fever
Symptoms include: A persistent cough Coughing blood or sputum Chest pain High fever Chills or night sweats Shortness of breath (dyspnea) Loss of energy and exhaustion Loss of appetite and unintended weight loss Poor growth in children How is TB and nontuberculous [brighamandwomens.org]
Another name for this is "hot tub lung," and symptoms are typically cough, weight loss, breathlessness, high fevers, wheezing, and fatigue. Symptoms can worsen with each hot tub exposure. [medicinenet.com]
The main symptoms and signs include high fever, diarrhoea, weight loss, abdominal pain, sweating, hiccups, aneamia, hepatomegalia and splenomegalia. The progression of disease may be very rapid and even fatal. [clinicalmicrobiologyandinfection.com]
- Constitutional Symptom
‡p value from multivariate analysis including COPD, age, not US born, constitutional symptoms, and infiltrate on radiograph. §54 (26%) patients excluded because of missing country of origin. ¶Fever, night sweats, weight loss, or appetite loss. [ncbi.nlm.nih.gov]
Most patients showed exclusive skin involvement without associated constitutional symptoms, and 4 patients (1 M. shigaense, 1 M. colombiense, and 2 M. abscessus) suffered from disseminated cutaneous lesions. [medicaljournals.se]
Infection presents in an indolent fashion with a chronic cough; constitutional symptoms are uncommon [5, 35]. [ajronline.org]
Respiratoric
- Sputum
Symptom questionnaires were administered at the time of sputum collection and clinical records and chest radiographs reviewed retrospectively. [ncbi.nlm.nih.gov]
Cough is a common complaint and can be either “dry” or “productive” of sputum. The color of the sputum is not helpful in the diagnosis. [nationaljewish.org]
- Cough
What Is Causing Your Chronic Cough? A chronic cough is a cough that persists over time. [medicinenet.com]
Click each one to learn more: Coughing It may be a chronic cough that you can’t get rid of, like a “coughing fit” or a cough that comes and goes. [aboutntm.com]
[…] that helps bring up mucus (huff cough), and aerobic exercise. [rarediseases.org]
Cough is a common complaint and can be either “dry” or “productive” of sputum. The color of the sputum is not helpful in the diagnosis. [nationaljewish.org]
When to See Your Doctor Go to your doctor right away if you have a cough that won’t go away, with fatigue, night sweats, shortness of breath, or weight loss. If your cough doesn’t improve with treatment, you might need to see a lung specialist. [foundation.chestnet.org]
- Hemoptysis
A 72-year-old woman with a past medical history of nontuberculous mycobacteria (NTM) pulmonary disease was admitted because of hemoptysis and acute renal failure. A chest X-ray showed interstitial infiltration over bilateral lung fields. [ncbi.nlm.nih.gov]
Symptoms may include: Fever Weight loss Cough Lack of appetite Night sweats Blood in the sputum (hemoptysis) Loss of energy Shortness of breath (dyspnea) Rarely, people will have no symptoms, and the infection is discovered when chest imaging is ordered [nationaljewish.org]
The most common symptoms include a persistent cough, fatigue, weight loss, night sweats, and occasionally shortness of breath (dyspnea) and coughing up of blood (hemoptysis). [rarediseases.org]
Hemoptysis was more common in this group than in other patients (Figure 2). [dovepress.com]
% Pulmonary NTM as primary diagnosis Cardiovascular conditions 2,441 47.4 COPD 1,724 33.5 Nutrition/hydration conditions 1,396 27.1 Bronchiectasis 769 14.9 Anemia 536 10.4 Pneumonia 467 9.1 Hemoptysis 438 8.5 Endocrine disorders 393 7.6 Postinflammatory [medscape.com]
- Dyspnea
In January 2001, three machinists at an automobile brake manufacturing facility in Ohio (plant A) were hospitalized with respiratory illness characterized by dyspnea, cough, fatigue, weight loss, hypoxia, and pulmonary infiltrates. [ncbi.nlm.nih.gov]
Symptoms may include: Fever Weight loss Cough Lack of appetite Night sweats Blood in the sputum (hemoptysis) Loss of energy Shortness of breath (dyspnea) Rarely, people will have no symptoms, and the infection is discovered when chest imaging is ordered [nationaljewish.org]
The most common symptoms include a persistent cough, fatigue, weight loss, night sweats, and occasionally shortness of breath (dyspnea) and coughing up of blood (hemoptysis). [rarediseases.org]
Symptoms include: A persistent cough Coughing blood or sputum Chest pain High fever Chills or night sweats Shortness of breath (dyspnea) Loss of energy and exhaustion Loss of appetite and unintended weight loss Poor growth in children How is TB and nontuberculous [brighamandwomens.org]
Thoracic disease manifests with cough or wheezing, fever, night sweats, dyspnea, weight loss, and chest pain. [ajronline.org]
- Sputum Production
Bronchiectasis is a clinical syndrome of cough, sputum production and recurrent respiratory infections that occurs in the setting of permanent damage to the airways of the lungs. [hopkinsmedicine.org]
The typical symptoms can be a persistent cough with sputum production, but usually there is no fever or weight loss. A syndrome where the right middle lobe or left lingula area of the lung is involved is sometimes called Lady Windermere syndrome. [medicinenet.com]
Such symptoms include cough, fatigue, shortness of breath (dyspnea), coughing up of blood (hemoptysis), excessive mucus (sputum) production, fever, night sweats, loss of appetite, and unintended weight loss. Wheezing and chest pain may also occur. [rarediseases.org]
Gastrointestinal
- Hiccup
The main symptoms and signs include high fever, diarrhoea, weight loss, abdominal pain, sweating, hiccups, aneamia, hepatomegalia and splenomegalia. The progression of disease may be very rapid and even fatal. [clinicalmicrobiologyandinfection.com]
Cardiovascular
- Hypertension
This condition is referred to as isolated systolic hypertension [32, 33]. [bmcpulmmed.biomedcentral.com]
Eyes
- Visual Impairment
They will also visually inspect the forest plot to assess the heterogeneity between trials. [cochranelibrary.com]
Skin
- Skin Disease
The Hospital for Skin Diseases, Chinese Academy of Medical Sciences in Jiangsu Province is the national center for leprosy control and prevention. [medicaljournals.se]
Nontuberculous mycobacteria (NTM) are all the other mycobacteria which can cause pulmonary disease resembling tuberculosis, lymphadenitis, skin disease, or disseminated disease. [en.wikipedia.org]
- Pruritus
Few patients complained of obvious pain (9.7%, 10/103) or pruritus (13.6%, 14/103) in the study. Treatment and outcome Treatment and prognosis information were available for 103 patients. All patients received antimicrobial therapy. [medicaljournals.se]
- Skin Rash
Dry mouth and skin may occur, and in rare cases, patients may experience skin discoloration. [ntminfo.org]
Neurologic
- Headache
Patients taking streptomycin should be aware of decreased hearing, tinnitus, and problems with balance, numbness or tingling, fever and headache. [ntminfo.org]
[…] tobramycin (Tobi) Dizziness or Vertigo Hearing loss Ringing in ears (tinnitus) azithromycin (Z-Pak), clarithromycin (Biaxin) Stomach (digestive, gastrointestinal upset) Decreased hearing Hepatitis ciprofloxacin (CIPRO), moxifloxacin (Avelox) GI upset Headache [medicinenet.com]
Treatment
[…] the treatment of these individuals. [ncbi.nlm.nih.gov]
Prognosis
PNTMI was not identified as a significant factor associated with prognosis by either univariate or multivariate analysis (hazard ratio [HR] = 0.950 and HR = 0.948, respectively). Georg Thieme Verlag KG Stuttgart · New York. [ncbi.nlm.nih.gov]
However, the severity, treatment, and prognosis may vary among species and patients. [medicaljournals.se]
Outlook (Prognosis) For those suffering from a severe case of NTM lung disease, their quality of life may be significantly impacted. It’s rare for NTM lung disease to be linked directly to instances of death. [ufhealth.org]
[…] multifactorial and includes consideration of: • How symptomatic the patient is • Whether the NTM lung disease is associated with pulmonary cavities • The patient’s pulmonary co-morbidities and whether they are compensated • The patient’s short- and long-term prognosis [prescriber.co.uk]
Etiology
Currently, NTM are recognized as etiological agents of several respiratory and extra-respiratory infections of immune-competent individuals. [ncbi.nlm.nih.gov]
The last few years brought several changes in this expanding field: The number of infections that can be associated with specific species as well as the number of new species as etiological agents has exploded due to the development of new diagnostic [link.springer.com]
The improvement was addressed according to visible scarring or recovery of the lesions, with or without the conversion to a negative etiological examination. [medicaljournals.se]
Conclusion Etiology and epidemiology of NTM infections highlight that NTMs are emerging pathogens, warranting more research. [intechopen.com]
Epidemiology
MeSH terms, Substances MeSH terms Bacterial Proteins/genetics Chaperonin 60/genetics Cross Infection/epidemiology* Cross Infection/microbiology DNA, Bacterial/genetics Hospitals* Humans Iran/epidemiology Mycobacterium Infections, Nontuberculous/epidemiology [ncbi.nlm.nih.gov]
Beyond the epidemiology, the need for host genetic and pathogen virulence studies, molecular epidemiologic analyses and clinical trials examining drug therapy cannot be understated. Much is to be done. [futuremedicine.com]
Prevention
[…] and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. [ncbi.nlm.nih.gov]
Currently, there no consensus on prevention among NTM experts. [medicinenet.com]