Presentation
She completed a graduate program and 4 years after presentation was in a leadership position in education. 11 The author of this case report defined menopause-related cognitive impairment as shown in the Box. [practicalneurology.com]
Quality statement 1: Diagnosing perimenopause and menopause Quality statement Women over 45 years presenting with menopausal symptoms are diagnosed with perimenopause or menopause based on their symptoms alone, without confirmatory laboratory tests. [nice.org.uk]
Women who are using a Mirena or other progesterone only contraceptive may also present a diagnostic challenge. [menopause.org.au]
Nesse artigo também abordamos as alterações hormonais presentes durante a transição menopausal, e o seu possível papel de "gatilho" no surgimento/exacerbação de quadros depressivos. [scielo.br]
PM Llorca has received over the past 5 years research grants, fees for presentations at congresses or participation on scientific advisory boards from Allergan, Gedeon Richter, Gilead Sciences, Janssen, Eli Lilly and Company, Lundbeck, Otsuka, Recordati [tandfonline.com]
Entire Body System
- Chills
Hot flashes frequently are followed by a cold chill. Night sweats are hot flashes at night that interfere with sleep. [menopause.org]
[…] vasomotor symptoms and urogenital symptoms 1, 2 vasomotor symptoms 2 reported in 50%-82% of women with natural menopause in United States symptoms include hot flashes, characterized by sudden sensation of heat in the upper body perspiration flushing chills [dynamed.com]
A major hot flash can induce facial and upper-body flushing, sweating, chills, and sometimes confusion. Having one of these at an inconvenient time (such as during a speech, job interview, or romantic interlude) can be quite disconcerting. [health.harvard.edu]
A chilled feeling after the heat. Hot flashes not only feel different for each person — they also can last for various amounts of time. Some women only have hot flashes for a short period of time during menopause. [my.clevelandclinic.org]
- Shivering
I actually felt a shiver of excitement at the prospect of getting back on track. I used to struggle with body confidence but am now super proud of the way I look. [refinery29.com]
Studies suggest that these women have a narrower zone of temperature regulation, and therefore smaller changes in core body temperature produce compensatory responses such as vasodilation, sweating, and shivering [ 23 ]. [intechopen.com]
- Inflammation
Decreasing estrogen levels during the menopause transition cause a variety of biological changes in a woman's body, leading to vaginal atrophy, the thinning, drying, and inflammation of the vaginal walls. [eurekalert.org]
Estradiol cream or patch (rather than pill form) is the safest route to go since oral estrogen can increase inflammation and risk of clot formation. [goop.com]
- Heat Intolerance
For this reason, serum TSH should be checked in all suspected perimenopausal cases with heat intolerance and disturbed sleep to determine the cause! [amboss.com]
Skin
- Alopecia
Jill Grunewald, FMCHC, author of the best selling Essential Thyroid Cookbook, and creator of the Reversing Alopecia program "There simply is not enough quality information available to women on perimenopause. Thankfully, Dr. [amazon.com]
Urogenital
- Sexual Dysfunction
Largely as a result of vaginal dryness, researchers noted that sexual satisfaction scores decreased while sexual dysfunction increased by about 30% during the perimenopause years. [eurekalert.org]
How Women 35 to 50 can Overcome Forgetfulness, Mood Swings, Insomnia, Weight Gain, Sexual Dysfunction and Other Telltale Signs of Hormonal Imbalance"; "What Your Doctor May Not Tell You About Perimenopause: Balance Your Hormones and Your Life From 30 [theguardian.com]
dysfunction References References Recommendation grading systems used American Association of Clinical Endocrinologists (AACE) guideline grading system grades of recommendation Grade A - best evidence level 1, or best evidence level 2 but adjusted upwards [dynamed.com]
Its symptoms include sexual dysfunction, weakness, fatigue, insomnia, loss of motivation, mood disorders and reduction of bone density. Though the symptoms aren't as severe as those of menopause, they can last for as long as 15 to 20 years. [smh.com.au]
Other factors, such as cigarette smoking and lack of exercise, were significantly associated with negative mood and reduced sexual interest. [scielo.br]
Neurologic
- Headache
“Night sweats and poor-quality sleep lead to mental fogginess,” Dweck says, and headaches and mood are dramatically impacted by hormonal shifts. [womansday.com]
Women can complain of symptoms of both excess oestrogen (headaches, breast tenderness, menstrual flooding) and symptoms of oestrogen deficiency (vaginal dryness, vasomotor symptoms). [menopause.org.au]
– premenstrual headaches can begin or increase during this time Weight gain – the high estrogen of early perimenopause makes gaining weight more likely Cramps – often times, cramps that once occurred in your 20s have returned Shorter cycles – slightly [womenshealthct.com]
Then there are some for whom perimenopause comes bearing migraine headaches (or making existing migraines worse). [glamour.com]
There’s a freight train running through your brain Some women suffer from incredible headaches with flu-like symptoms that make them feel like they can’t get out of bed. [nuffieldhealth.com]
- Forgetful
The degrees of distractibility and forgetfulness become intrusive and disruptive. Interest in sex decreases while there is an increased need for non-sexual contact. [medcraveonline.com]
You’re forgetful and can’t concentrate No you’re not losing your mind; hormones are clouding your thought patterns and blocking memory retrieval. [nuffieldhealth.com]
If you’re forgetting things more frequently, experiencing an unusually painful headache, have trouble concentrating on tasks you used to ace, or are feeling more depressed than usual for two weeks or more, talk to your doctor. 5 of 5 [womansday.com]
[…] occurred in your 20s have returned Shorter cycles – slightly shorter cycles by an average of 27 days Low libido – lack of interest in sex is common Vaginal dryness – this can be caused by the decline in estrogen levels Brain fog – memory issues or being forgetful [womenshealthct.com]
How Women 35 to 50 can Overcome Forgetfulness, Mood Swings, Insomnia, Weight Gain, Sexual Dysfunction and Other Telltale Signs of Hormonal Imbalance"; "What Your Doctor May Not Tell You About Perimenopause: Balance Your Hormones and Your Life From 30 [theguardian.com]
- Dizziness
Hot flushes and irregular periods are the primary clues, but how many thirty- or fortysomething women have not experienced at least one of the following: fatigue, weight gain, migraines, insomnia, joint aches, skin problems, breast tenderness, dizziness [theguardian.com]
Here are a few of those symptoms: Hot flashes (which can include sweating, tingling, electrical sensations, flushing from the extremities up through the torso and head, nausea, dizzy spells, etc.) [medium.com]
But if you’ve got period changes and any of the following list, it could be hormonal: sleeplessness, emotional upheaval, joint pain, loss of libido, weight gain, anger, irritability, low mood, poor concentration, memory problems, anxiety, dizziness, irritability [redonline.co.uk]
In the first nights of taking progesterone, you can feel dizziness or "drunk" if you are awakened within an hour or two of taking it. [cemcor.ubc.ca]
It can reduce the number and severity of hot flashes. footnote 5 Possible side effects include sleepiness, dizziness, and swelling. Other Treatment Many women have turned to alternative medicine for menopause symptom relief. [healthlinkbc.ca]
- Memory Impairment
Although cognitive impairment has been shown to occur during perimenopause, 1 this is not routinely incorporated into assessments of memory and other cognitive impairments of women in this stage of life. [practicalneurology.com]
Treatment
It does not need treatment, but treatment can help lessen symptoms. Treatment includes hormones, antidepressants, and lifestyle changes. [hopkinsmedicine.org]
It does not need treatment, but treatment can help ease symptoms. Treatment includes hormones, antidepressants, and lifestyle changes. [healthlibrary.brighamandwomens.org]
Treatments such as black cohosh and soy. To learn more, see Other Treatment. Home Treatment A healthy lifestyle may help you manage menopause symptoms. [healthy.kaiserpermanente.org]
Treatment can decrease pain related to sex and relieve vaginal dryness. Your healthcare provider will discuss the risks and benefits of perimenopause treatment with you and recommend the best option based on your needs. [my.clevelandclinic.org]
Prognosis
Outlook / Prognosis Are there any health risks associated with perimenopause? There are health risks associated with menopause, which happens right after perimenopause. Estrogen plays an important role in preserving your bones. [my.clevelandclinic.org]
Etiology
[…] vasomotor symptoms (i.e., hot flashes) Clonidine and/or gabapentin References: [3] [11] [12] [13] [14] Disorders related with cessation of menstruation Premature menopause ( menopause precox ) Definition : : cessation of periods before the age of 40 Etiology [amboss.com]
[…] lead patients and physicians to think another cognitive disorder is present, leading to a misdiagnosis. 11 Similarly, if symptoms of a menopause-related cognitive impairment persist past the transition or significantly interfere with function, another etiology [practicalneurology.com]
Epidemiology
Its multidisciplinary membership of 2,000 leaders in the field--including clinical and basic science experts from medicine, nursing, sociology, psychology, nutrition, anthropology, epidemiology, pharmacy, and education--makes NAMS uniquely qualified to [eurekalert.org]
Clinical and epidemiological data on women in perimenopause are limited, and what data there are come primarily from Caucasian populations. [ncbi.nlm.nih.gov]
Epidemiology of women and depression. J Affect Disord. 2003 Mar. 74(1):5-13. [Medline]. Klaiber EL, Broverman DM, Vogel W, Kobayashi Y. Estrogen therapy for severe persistent depressions in women. Arch Gen Psychiatry. 1979 May. 36(5):550-4. [medscape.com]
Repeated epidemiological studies throughout the world show that depression and anxiety prevalence rates are approximately 2:1 for women to men. [intechopen.com]
Pathophysiology
The data collected may also be linked with data from other perimenopausal depression protocols (e.g., DNA, psychophysiology tests, treatment studies, etc.) for the purposes of better understanding the diagnosis, pathophysiology, and treatment response [clinicaltrials.gov]
Postmenopause : : the time period beginning 12 months after the last menstrual period References: [1] [2] [3] [4] [5] Pathophysiology ↓ Ovarian function → ↓ estrogen and progesterone levels → loss of negative feedback to the gonadotropic hormones → ↑ [amboss.com]
[…] cumulative prevalence of 85% for vasomotor symptoms.26 Vasomotor symptoms cause a substantial amount of distress and reduction in health-related quality of life (HRQOL).27 Despite their high prevalence, surprisingly little is understood about their exact pathophysiology [ncbi.nlm.nih.gov]
Prevention
Some studies claim they reduce hot flashes, prevent osteoporosis, treat acne, and promote cardiovascular health. Research on their ability to fight other perimenopausal symptoms, however, has been inconclusive. [flo.health]
Preventive Services Task Force (2017). Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: U.S. Preventive Services Task Force recommendation statement. JAMA, 318(22): 2224–2233. DOI: 10.1001/jama.2017.18261. [healthy.kaiserpermanente.org]
Preventive Services Task Force[ 46 ] and the Canadian Task Force on Preventive Health Care[ 47 ]) decided that HT, especially taken in this regimen, does not fit the profile of a compound for the prevention of diseases and have thus changed their recommendations [ncbi.nlm.nih.gov]
Perimenopause seems to be the preventative health buzzword du jour with two guides to be released in November to help young women understand their next "life change." [independent.co.uk]
They act by preventing the ovary from releasing its own estrogen and progesterone. They also work to inhibit ovulation, thus preventing pregnancy. [medicinenet.com]