Presentation
We report the case of a newborn infant with no obstetric antecedents who presented spontaneous intraventricular hemorrhage. Coagulation studies showed alterations, and we found severe factor V deficiency. [analesdepediatria.org]
Figures and Tables - Figure 2 Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies. [cochranelibrary.com]
Entire Body System
- Developmental Delay
Major neurodevelopmental disability: cerebral palsy, developmental delay (Bayley Mental Developmental Index (Bayley 1993; Bayley 2006) or Griffiths Mental Development Scale assessment (Griffiths 1954) more than two SD below the mean), intellectual impairment [cochranelibrary.com]
Cardiovascular
- Thrombosis
Although we cannot establish the proportion of thrombosis exclusively triggered by inherited thrombophilic disorders the evidence of thrombosis per se within germinal matrix microvasculature remains an important key factor in the pathogenesis of GM‐IVH [cochranelibrary.com]
Workup
X-Ray
- Pneumothorax on Chest X-Ray
Pneumothorax (on chest X‐ray) (Outcome 1.5) See:Analysis 1.5 The Fulia 2003 study of 60 infants was the only study to report data for pneumothorax (on chest X‐ray) and found no difference (typical RR 0.67, 95% CI 0.12 to 3.71; typical RD −0.03, 95% CI [cochranelibrary.com]
Treatment
Heparin vs placebo/no treatment [cochranelibrary.com]
Etiology
The etiology of GM‐IVH is multifactorial, not completely elucidated, and involves the intrinsic vulnerability of the germinal matrix (Perlman 1983). [cochranelibrary.com]
Pathophysiology
Taking into account the pathophysiological mechanisms of GM‐IVH development, the controversial findings from retrospective studies on GM‐IVH incidence during heparin administration and the increasing use of heparin for catheter patency in preterm newborns [cochranelibrary.com]
Prevention
Antithrombin versus placebo for the prevention of intraventricular hemorrhage in very preterm infants Antithrombin versus placebo for the prevention of intraventricular hemorrhage in very preterm infants Patient or population: very preterm infants at [cochranelibrary.com]
Pathogenesis and prevention of intraventricular hemorrhage. Clin Perinatol. 2014;41(1):47-67. doi: 10.1016/j.clp.2013.09.007. Epub 2013 Dec 12. [ Links ] 14. Lizama O, Hernandez H, Rivera Tori A. [scielo.org.pe]