Presentation
In contrast, the patient in the present study had a rapid decrease in VPA to 40.18 mg/L and completely recovered consciousness within 24 hr after an intensive therapy. [onlinelibrary.wiley.com]
Similar articles Abstracts of Presentations at the Association of Clinical Scientists 143rd Meeting Louisville, KY May 11-14,2022. [No authors listed] [No authors listed] Ann Clin Lab Sci. 2022 May;52(3):511-525. Ann Clin Lab Sci. 2022. [pubmed.ncbi.nlm.nih.gov]
NASH rat presented significantly elevated body weight and liver weight index, increased ROS content, declined SOD activity, enhanced liver function and inflammatory factors expression, and upregulated NF-κB mRNA and protein levels compared with control [x-mol.com]
Entire Body System
- Asymptomatic
Nearly one-half of these patients were asymptomatic (15/31; 48.4%). In 11 patients (35.5%) among those with symptoms, the symptoms of toxicity were categorised with a strong causality to the respective antifungal. [pubmed.ncbi.nlm.nih.gov]
Treatment
Due to low endogenous clearance of VPA and lack of specific antidote, extracorporeal treatment (EXTR) is reserved for severe cases in addition to standard therapy as suggested by the EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup 2. [onlinelibrary.wiley.com]
Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U10 Miscellaneous (drug allergy, mutagens, teratogens...) [pascal-francis.inist.fr]
Polyene phosphatidyl choline (PPC) is widely used in clinic for liver disease treatment. The effect and mechanism of PPC on NASH have not been fully elucidated. [x-mol.com]
Azoles versus conventional amphotericin B for the treatment of candidemia: A meta-analysis of randomized controlled trials. Osa S, Tashiro S, Igarashi Y, Watabe Y, Liu X, Enoki Y, Taguchi K, Mayumi T, Miyazaki Y, Takesue Y, Matsumoto K. [pubmed.ncbi.nlm.nih.gov]
Prevention
Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture [J]. Pharmacological Research, 2001(5):431. [58.192.131.136]
For this reason, blood purification therapies aiming to quickly remove both protein-bound and free VPA should be considered in order to rapidly improve mental status and prevent further complications in some cases. [onlinelibrary.wiley.com]