Presentation
The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
T0: No evidence of primary tumor is present. N0: No evidence of regional lymph node metastases is present. M0: No evidence of distant metastasis is observed. Tis: Carcinoma in situ is present. [emedicine.medscape.com]
[…] in the WISC-IV), and 11.6% presented both. [frontiersin.org]
If dental abnormalities are present, treatment may be recommended to correct problems. [healthline.com]
The first hit is a heterozygous MEN1 germline mutation, inherited from one parent (familial cases) or developed in an early embryonic stage (sporadic cases) and present in all cells at birth. [en.wikipedia.org]
Entire Body System
- Multiple Congenital Anomalies
(p 174-177) Psychogenic purpura Erythrocyte membrane sensitization Gardner-Diamond purpura Psychological purpura Thrombocytopenia multiple congenital anomaly Patients' and doctors' sex and ethnicity Samson Gardner syndrome Gardner's syndrome Gardner Morrisson [koolearn.com]
Eyes
- Retinal Pigmentation
Other symptoms associated with Gardner syndrome include: Polyps of the stomach and small intestine Dental abnormalities Benign bone growths or osteomas Benign skin and connective tissue tumors called epidermoid cysts and desmoid tumors Retinal pigment [news-medical.net]
CHRPE (congenital hypertrophy of retinal pigment epithelium), a pigmented, flat spot affecting the outer layer of the retina. Gardner syndrome affects different people in different ways. [my.clevelandclinic.org]
pigment epithelium (CHRPE), in addition to multiple adenomatous polyps of the colon. [en.wikipedia.org]
Psychiatrical
- Social Isolation
For example, some HIP children are socially isolated because they encounter problems meeting intellectual peers. Alongside, some children who have received a clear diagnosis of ASD also show high cognitive abilities attested by intelligence tests. [frontiersin.org]
Neurologic
- Irritability
Asked by Alejandra Buckley They determined that Samson’s behavior, as described in Judges 13 to 16, met the diagnostic criteria for deceitfulness, a failure to conform to social norms and defiance of the law, impulsivity, irritability and aggressiveness [bankruptingamerica.org]
Irritable bowel syndrome DOID:9778 ! irritable bowel syndrome GARD:0010260 ! Macular degeneration DOID:4448 ! macular degeneration GARD:0010260 ! Macular degeneration OMIM:607921 ! Retinitis Pigmentosa 30 GARD:0010261 ! Obesity DOID:9970 ! [github.com]
Workup
X-Ray
- Multiple Colonic Polyps
It is an autosomal dominant syndrome characterized by multiple colonic polyps predisposing to carcinoma of the colon, osteomas of the skull, epidermoid cysts, and fibromas. It is associated with mutation of the APC gene. [curofy.com]
The most common symptom of Gardner syndrome is the development of multiple colon polyps. While the number of polyps can vary from person to person, some individuals develop hundreds of them. [my.clevelandclinic.org]
Once 20 or more polyps and/or multiple higher risk polyps are found, removal of the colon is recommended in order to prevent colon cancer. If dental abnormalities are present, treatment may be recommended to correct problems. [healthline.com]
Treatment
There are two main types of clinical studies: Clinical trials determine if a new test or treatment for a disease is effective and safe by comparing groups receiving different tests/treatments. [rarediseases.info.nih.gov]
Treatments can vary significantly depending on your unique situation, and may include medications, surgical treatments, dental procedures or a combination of methods. [my.clevelandclinic.org]
The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
Prognosis
The long-term prognosis depends on the age of diagnosis and the symptoms experienced. Is there a cure for Gardner syndrome? No. There is no known cure for Gardner syndrome. [my.clevelandclinic.org]
Prognosis Colorectal cancer during childhood is associated with a poor prognosis, mainly attributed to delayed diagnosis, greater tumor virulence, and the advanced stage of disease at presentation. [emedicine.medscape.com]
Mathematically gifted children: developmental brain characteristics and their prognosis for well-being. Roeper Rev. 30, 181–186. doi: 10.1080/02783190802199594 CrossRef Full Text | Google Scholar O'Boyle, M. W., Alexander, J. E., and Benbow, C. [frontiersin.org]
Etiology
Results from a second study (Ruthsatz et al., 2015) point to genetic evidence suggesting a shared etiology between ASD and “Prodigies.” [frontiersin.org]
Epidemiology
More than a million Americans are estimated to be living with colon cancer. [42] Epidemiology In the general population, the lifetime risk of developing colorectal carcinoma is 5-6%. [emedicine.medscape.com]
Pathophysiology
The pathophysiology of edema formation in the nephrotic syndrome. Kidney Int. 2012;82:635. [ Links ] 11. Dou Y, Zhu F, Kotanko P. Assesment of extracellular fluid volume and fluid status in hemodialysis patients. [scielo.isciii.es]
Pathophysiology [ edit ] MEN1 follows Knudson’s “two-hit” model for tumor suppressor gene carcinogenesis (30). [en.wikipedia.org]
Prevention
Because people with Gardner’s syndrome have a higher risk of developing colon cancer, treatment is usually aimed at preventing this. [healthline.com]
And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
Prevention How can I reduce my risk for Gardner syndrome? Because Gardner syndrome is an inherited condition, there is no known way to prevent it from occurring altogether. [my.clevelandclinic.org]
It is a vital step towards preventing disease transmission to the next generation. Besides genetic testing, colonoscopy and X-Ray of the long bones and jaw bone are the routine examinations to diagnose Gardner syndrome. [news-medical.net]
IMALIVE Provides help with suicide intervention, prevention, awareness, and education and hope through online crisis chat, educational on-campus and virtual college events, and awareness campaigns. [rarediseases.info.nih.gov]