Presentation
In the literature, S marcescens infections of the lower extremity have presented as granulomatous ulceration, abscess, bullous cellulitis, and necrotizing fasciitis. [ncbi.nlm.nih.gov]
Entire Body System
- Sepsis
Serratia marcescens is an unusual cause of sepsis and neurological spread is especially ominous. To report the case of a 34-week neonate who developed this rare condition and to discuss diagnostic and therapeutic measures. [ncbi.nlm.nih.gov]
Serratia marcescens is an emerging cause of preterm sepsis but its epidemiology is still largely unknown. [aricjournal.biomedcentral.com]
Cerebral abscesses are extremely rare in neonates and usually arise in the setting of sepsis in patients with several other morbid conditions. [scielo.br]
- Pain
We herein report the case of a 54-year-old woman who presented with progressive low back pain and fever with a root sign. She underwent surgical decompression, with an immediate improvement of the low back pain. [ncbi.nlm.nih.gov]
[…] management procedures at an outpatient pain clinic. [journals.lww.com]
- Wound Infection
Whole-genome sequencing was performed on S. marcescens VGH107, an isolate from wound infection secondary to Trimeresurus mucrosquamatus bite. [ncbi.nlm.nih.gov]
The bacteria is pathogenic to humans and is responsible for hospital-acquired infections (HAIs), particularly through catheters, urinary tract infections, and wound infections. [quiplabs.com]
S. marcescens is involved in hospital-acquired infections, particularly in urinary tract and wound infections. Serratia species cause 1.4% of nosocomial bloodstream infections with an associated mortality of 25% [in USA]. [genetex.com]
- Swelling
She developed swelling and cellulitis with tissue necrosis. Wound debridement was performed. Pus and tissue biopsy cultures yielded Serratia marcescens sensitive to fluoroquinolones, aminoglycosides, third-generation cephalosporins and carbapenems. [ncbi.nlm.nih.gov]
Seton Infection: Serratia Marcescens: 57-Year-Old White Female with 1 day History of Redness, Swelling, and Pain in her Right Eye. Available from:. [Last accessed on 2005 Mar 5]. 3. Haas J, Larson E, Ross B, See B, Saiman L. [jacmjournal.org]
CASE REPORT An 81-year-old man with progressive renal failure and multiple medical problems presented with erythema, warmth, and swelling of his right lower extremity. [journals.lww.com]
- Surgical Procedure
FINDINGS: The outbreak involved 14 patients, five of whom required more than one surgical procedure. S. marcescens was isolated from cerebrospinal fluid, brain tissue, sputum and other secretions. [ncbi.nlm.nih.gov]
Ten cases presented with symptoms following a surgical procedure. [cureus.com]
Of the 16 cases reviewed, 6 (38%) underwent debridement, 2 (12%) incision and drainage, and 2 (12%) amputation; 6 (38%) patients had no surgical procedures to manage their infection. Four (25%) patients required skin grafting. [journals.lww.com]
Gastrointestinal
- Nausea
Five months after the initiation of automated peritoneal dialysis (APD), the patient presented with abdominal pain and nausea to our PD clinic. [revistanefrologia.com]
- Vomiting
However, on day 60, conditions worsened when fever, vomiting and seizures started, which after CT examination were considered to be secondary to abscess rupture into the subarachnoid space. [scielo.br]
Skin
- Erythema
Erythema with multiple abscesses on the left ankle and leg at presentation (A), day 1 following surgical debridement of infected tissues (B), and 2 months later with complete healing following a skin graft (C). Figure 2. [mdedge.com]
CASE REPORT An 81-year-old man with progressive renal failure and multiple medical problems presented with erythema, warmth, and swelling of his right lower extremity. [journals.lww.com]
Psychiatrical
- Fear
Because of the total loss of visual functions and the fear of possible development of sympathetic ophthalmia, enucleation rather than vitrectomy or evisceration was performed. [healio.com]
Neurological spread involving the meninges or the parenchyma itself is especially feared since this patient subgroup frequently has a very poor neurological outcome 2. [scielo.br]
Neurologic
- Meningism
Infectious Diseases physician was consulted, lumbar puncture was performed and purulent meningitis was confirmed. [ncbi.nlm.nih.gov]
- Headache
Previously healthy individual, admitted to Orthopaedic Department for routine arthroscopy, approximately within 24 hours after operation was performed complained of headache and fever. [ncbi.nlm.nih.gov]
Churg-Strauss syndrome, multiple myeloma, or combined variable immune deficiency) Symptoms at time of initial positive Serratia marcescens included: nasal discharge (55%), nasal congestion/obstruction (34%), headache/facial pressure (34%), decreased sense [alliedacademies.org]
Workup
[…] fasciitis of the lower extremity; both organisms had identical antibiograms. 15 The portal of entry in another case was an infected intravenous catheter with bacteremia leading to the development of cellulitis at a distant site. 7 Despite an extensive workup [journals.lww.com]
Initial workup revealed an embolus in the right popliteal artery as well as lesions consistent with infarction in the spleen and bilateral kidneys on abdominal CT scan. [cureus.com]
Treatment
Clinically, all patients treated with empirical first-generation cephalosporin showed treatment resistance, and oral quinolone monotherapy was the most preferred antibiotic regimen without treatment failure, with an average treatment duration of 25 days [ncbi.nlm.nih.gov]
Prognosis
BACKGROUND: It is known that infections with Serratia marcescens can take a progressive course in preterm infants and that meningoencephalitis with this pathogen exhibits an extremely bad neurologic prognosis. [ncbi.nlm.nih.gov]
Based on these and several other reports of S. marcescens outbreaks, meningitis alone can be recognized as an indicator of poor prognosis. [scielo.br]
DISCUSSION The prognosis for vision in metastatic endophthalmitis is guarded.3 In cases with involvement of the posterior segment where the vitreal inflammatory reaction prevents fundus visualization, the outcome is generally very poor.6,7 Regardless [healio.com]
Etiology
Abstract We report a case of postsurgical wound infection of polymicrobial etiology caused by Serratia marcescens and Pseudomonas aeruginosa following the use of a radial forearm free flap for oncological tongue reconstruction. [ncbi.nlm.nih.gov]
The etiology of this phenomenon remains unknown, and there is no evidence that gram-negative rods such as S. marcescens have an increased ability to increase to the matrix ligands that are associated with sterile vegetation but are important in the etiology [cureus.com]
Epidemiology
KEYWORDS: Serratia; beta-lactamases; infection control; molecular epidemiology [ncbi.nlm.nih.gov]
There have been many reports concerning the identification, antibiotic susceptibility, pathogenicity, epidemiological investigations and typing of this organism. Accurate identification is important in defining outbreaks. [doi.org]
J Clin Microbiol 1978;8:46.Google Scholar 28.Grimont, PAD, Grimont, F, Proteinase zymograms of Serratia marcescens as an epidemiological tool. [cambridge.org]
the journal of the Society for Healthcare Epidemiology of America. [shea-online.org]
Pathophysiology
We discuss the pathophysiology of the lesions and the impact of the various imaging methods. [ncbi.nlm.nih.gov]
[…] opportunistic pathogen in humans. [10] Derivatives of prodigiosin have recently been found to have immunosuppressive properties and antitumor activity in vivo [11, 12] and are also currently being considered as a candidate treatment for Chagas disease. [13] Pathophysiology [emedicine.medscape.com]
Prevention
An investigation was conducted to identify potential sources of contamination and prevent further infections. METHODS: Cases were defined as S. marcescens BSIs in patients receiving PN from the pharmacy between January and March 2011. [ncbi.nlm.nih.gov]
The overall case fatality rate for the entire epidemic period was 16.6% (23% in NICU) and the death rate of infection in S. marcescens exposed population was 2% (3% in NICU).Preventive measures The first preventive measures adopted to prevent cross-transmission [elsevier.es]
Residency Program, Brigham and Women's Hospital/Massachusetts General Hospital, Boston, MA Financial support: Internal support from Centers for Disease Control and Prevention, Atlanta, GA. [journals.lww.com]