Presentation
[…] pain Absent Absent Present Present Jaundice Present Present Present Present Pruritus Present Absent Present Present Hepatomegaly Absent Absent Present Present Splenomegaly Absent Absent Absent Present Urinary hyperpigmentation Present Present Present [ncbi.nlm.nih.gov]
Here, we report an unusual presentation of Stauffer’s syndrome. Case Presentation A 30-year-old Pakistani male presented to our hospital complaining of a 3-day history of hematuria and left flank pain. [karger.com]
Immune System
- Abdominal Lymphadenopathy
In the computerized tomography (CT) scan we did not find liver lesions, bile duct dilatation, abdominal lymphadenopathies or lesions consistent with metastases in bone. [revistanefrologia.com]
Entire Body System
- Sepsis
[…] phase reactants (CRP, erythrocyte sedimentation rate)2,3,5 with an absence of liver metastases, bile duct obstruction and other hepatocellular disorders with predominant cholestatic pattern (viral, drug-induced and alcoholic hepatitis, hypoperfusion/sepsis [revistanefrologia.com]
- Pseudotumor
[…] described in relation to malignant tumours (renal carcinoma, lymphoma, chronic lymphocytic leukaemia, medullary thyroid cancer, leiomyosarcoma, prostate cancer, renal sarcoma and malignant schwannoma) or benign lesions (benign haemorrhagic renal cyst, pseudotumoral [revistanefrologia.com]
- Malaise
He developed progressively of progressive asthenia and malaise. In the laboratory tests, we found a cholestatic pattern with bilirubin of 3.96mg/dl (direct dominance), GGT 490U/l, alkaline phosphatase 581U/l and normal transaminases. [revistanefrologia.com]
Liver, Gall & Pancreas
- Liver Dysfunction
It has been related to many paraneoplastic syndromes, ranging between neuromyopathy, polycythemia, malignant hypercalcemia, anemia, and liver dysfunction [2]. [bmcurol.biomedcentral.com]
Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arises due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms, though the specific pathogenesis is currently unknown. [en.wikipedia.org]
Epilepsy and liver dysfunction in association with hypernephroma. Br Med J. 1967 Dec 16;4(5580):660–661. [PMC free article] [PubMed] [Google Scholar] Walsh PN, Kissane JM. Nonmetastatic hypernephroma with reversible hepatic dysfunction. [ncbi.nlm.nih.gov]
Breast
- Agalactia
During hospitalization because of catheter-related bacteriemia due to S. agalactiae, the patient presented with jaundice and pruritus. [revistanefrologia.com]
Neurologic
- Seizure
A month later, he developed spontaneous subdural haematoma with secondary seizures; conservative treatment was administered and the patient died. [revistanefrologia.com]
Workup
Lichtstein Medicine Journal of general internal medicine 2006 A patient who presented with abdominal pain and cholestatic jaundice in whom RCC was incidentally found during initial workup and resolved completely after surgical resection of the tumor illustrates [semanticscholar.org]
We present a case of a patient whose workup for hyperbilirubinemia led to her diagnosis of renal cell carcinoma. [journals.lww.com]
A metastatic workup, including a CT scan with intravenous contrast of the chest, abdomen, and pelvis, revealed no evidence of metastatic disease. [ncbi.nlm.nih.gov]
Serum
- Thrombocytosis
Stauffer's syndrome is a rare paraneoplastic manifestation of renal cell carcinoma (RCC) that is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, α-2-globulin, and γ-glutamyl transferase, thrombocytosis, prolongation of [ncbi.nlm.nih.gov]
Treatment
Thus, as nephrologists, we face new diagnostic and treatment challenges every day. [revistanefrologia.com]
Treatment should be focused on the renal neoplasm rather than liver function, however some symptoms resulting from hepatic derangement can pose a challenge to manage in the preoperative period. [urologynews.uk.com]
This may allow early recognition and treatment of an occult malignancy. [ncbi.nlm.nih.gov]
Immune checkpoint blockade (ICB) represents a novel and feasible treatment option available in the current treatment landscape of metastatic RCC [27,28,29,30]. [ejim.springeropen.com]
Prognosis
As described, both cases had a poor prognosis, with a survival rate of less than one month. [revistanefrologia.com]
Prognosis The prognosis is dismal. Lymphangiosarcomas are extremely aggressive tumors with a high local recurrence rate and a tendency to metastasize early to many areas. Long-term survivors are the exceptions. [emedicine.medscape.com]
Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis; The Open Car diovascular Medicine Journal, 2014 (8): 61-67. 5. [romanianjournalcardiology.ro]
However, this syndrome must be differentiated from jaundice caused by metastatic infiltration of the liver, which carries a considerably worse prognosis [5]. [ncbi.nlm.nih.gov]
Etiology
Further evaluation regarding the etiology of her underlying liver disease was undertaken. [ncbi.nlm.nih.gov]
These cha-racteristics make it the ideal method for defi ning the etiology and anatomic location of the culprit vessel/ segment or ruling out ACS16. [romanianjournalcardiology.ro]
Epidemiology
For the IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005; 366: 1059-62. Parikh RM, Joshi SR, Menon PS, Shah NS. Index of central obesity - A novel parameter. [content.sciendo.com]
Epidemiology Frequency Currently, approximately 400 cases of Stewart-Treves syndrome are reported in the world literature. [emedicine.medscape.com]
Pathophysiology
Appareil digestif pathologie Appareil urinaire pathologie Cytokine Foie pathologie Rein pathologie Tumeur maligne Voie biliaire pathologie Keyword (en) Carcinoma Intrahepatic cholostasis Case study Human Grawitz tumor Interleukin 6 Paraneoplastic syndrome Pathophysiology [pascal-francis.inist.fr]
The pathophysiology remains poorly understood with the most accepted theory being tumour overexpression of cytokines. [urologynews.uk.com]
Interleukin-6 (IL-6) has been proposed to play a major role in the pathophysiology of this syndrome [3, 5, 9]. [springermedizin.de]
Pathophysiology The underlying pathophysiology of this paraneoplastic manifestation has yet to be determined, but three mechanisms have been proposed. [ejim.springeropen.com]
Prevention
Prevention of tumor progression in Stewart-Treves syndrome with a low dose of pazopanib. J Dermatol. 2019 Feb 25. [Medline]. [emedicine.medscape.com]
The prognosis of this patient depends largely on secondary preventative measures such as smoking cessation and lifestyle improvement. The medical ma-nagement for MINOCA patients is still a matter of debate and future research is needed. [romanianjournalcardiology.ro]