Presentation
Clinical data were analyzed as to predisposing factors, clinical presentation, antibiotic susceptibility, treatment selection, and clinical outcomes. RESULTS: Median age at presentation was 65 years (range, 16-98). [ncbi.nlm.nih.gov]
Entire Body System
- Sepsis
The facultative pathogen S. maltophilia, which most often causes nosocomial infections, may cause severe sepsis and liver abscess. [ncbi.nlm.nih.gov]
- Fever
Keywords Stenotrophomonas maltophilia Stenotrophomonas Xanthomonas Pneumonia Neutropenia Neutropenic fever Fever of unknown origin Background Infection is the major cause of neutropenic fever in patients receiving chemotherapy, with the pulmonary system [mrmjournal.biomedcentral.com]
She presented with fever, abdominal pain, and cloudy peritoneal effluent. The organism isolated from the effluent was S. maltophilia. [ncbi.nlm.nih.gov]
Patient was started on levofloxacin to which it was sensitive for 2 weeks, the fever subsided thereafter, and repeat blood culture was negative. [atmph.org]
Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders [en.wikipedia.org]
- Weakness
In the present study, all of the samples had motility, 100% of isolates had strong swimming motility, 66.66% had strong swarming motility and 33.33% had weak twitching motility. 66.66% of isolates had strong twitching motility and 33.33% of them had weak [alliedacademies.org]
CV staining also revealed weak, moderate or strong adherence of S. maltophilia isolates to PS ( Table 2 ). [scielo.org.ar]
It thrives in wet and moist conditions, and mainly affects patients whose immune systems have been compromised by infection or weakness. [slideshare.net]
The patient had originally been admitted approximately one month prior for dehydration, increasing weakness, diabetic ketoacidosis and acute kidney injury. [omicsonline.org]
Rhinoscleroma, Klebsiella pneumonia Klebsiella granulomatis Granuloma inguinale Klebsiella oxytoca Escherichia coli : Enterotoxigenic Enteroinvasive Enterohemorrhagic O157:H7 O104:H4 Hemolytic-uremic syndrome Enterobacter aerogenes / Enterobacter cloacae Slow/weak [en.wikipedia.org]
- Surgical Procedure
Risk factors associated with S. maltophilia infections include immunosuppressive therapy, admission to the Intensive Care Unit (ICU), advanced age, prolonged hospital stay, long term antimicrobial therapy and surgical procedures [ 14 ]. [ncbi.nlm.nih.gov]
Respiratoric
- Pneumonia
pneumonia due to this organism 8, 11, further analysis was limited to the patients without radiological evidence of pneumonia. [erj.ersjournals.com]
Abstract Ventilator-acquired pneumonia and hospital community-acquired pneumonia are frequently caused by Gram-negative and -positive bacteria. [ncbi.nlm.nih.gov]
- Pleural Effusion
It was first found in a pleural effusion in 1943 and given the name Bacterium bookeri. It was then renamed to Pseudomonas maltophilia in 1961. [en.wikipedia.org]
effusions and cavitations are rarely observed.20 As many S maltophilia infections are polymicrobial, clinicians should be extremely cautious when interpreting radiological findings (especially in patients with cancer), as several copathogens (eg, Pseudomonas [journals.sagepub.com]
Pulmonary infiltrates on examination by radiology appear lobular-shaped and unusual pleural effusions. [24] In one of the retrospective studies carried out to analyse the effect of inhalation of tobramycin for the treatment of P. aeruginosa infections [ijmm.org]
Skin
- Ecthyma
This was rarely reported as cutaneous pathogenic organism causing cellulitis-like lesions, paronychia, mucocutaneous ulcers and ecthyma gangrenosum in immunocompromised individuals. [ncbi.nlm.nih.gov]
Ecthyma gangrenosum has been reported in association with S. maltophilia infection in a patient with a recent allogeneic bone marrow transplantation [ 5 ]. [omicsonline.org]
Nevertheless, other manifestations, for example, wound/soft tissue infections (ie, ecthyma gangrenosum), cellulitis, mastoiditis, meningitis, peritonitis, bone and joint infections, urinary tract infections, conjunctivitis, and otitis media have also [journals.sagepub.com]
Reported syndromes include cellulitis, multiple subcutaneous nodules, ecthyma gangrenosa, mucous membrane ulcerations, necrotizing gingivitis, and myositis ( 19, 55, 56, 90 ). [antimicrobe.org]
Neurologic
- Meningism
Stenotrophomonas maltophilia should be considered as a potential cause of meningitis, especially among severely debilitated or immunosuppressed patients. [ncbi.nlm.nih.gov]
Anderson Cancer Center, Houston, Texas Restricted access Rhoton Anatomy Links Abstract ✓ The authors report two cases of meningitis caused by Stenotrophomonas maltophilia in cancer patients following placement of an Ommaya reservoir for treatment of meningeal [thejns.org]
The bacterium can also cause infection of the urinary tract infection, eyes, bone/join; meningitis (inflammation of the membranes protecting the brain and spinal cord); endocarditis (infection of the heart’s inner lining); and bacteremia (bacteria entering [prod.hopkins-abxguide.org]
Workup
In patient with abnormal thoracic CT, it is sensible for us to carry out detailed workup focusing on the pulmonary system. [mrmjournal.biomedcentral.com]
S. maltophilia is resistance to most of routinely used antibiotic so this case highlights the importance of early detection and antibiotic sensitivity workup. [atmph.org]
Initial workup showed elevated troponin and procalcitonin. Chest X-ray findings were suggestive for left lower lobe pneumonia. [cureus.com]
Serum
- Neutropenia
Severe neutropenia (adjusted hazard ratio [HR] 5.24, p =0.013), shock at the onset of BSI (adjusted HR 6.05, p CONCLUSION: S. maltophilia BSIs show high mortality, which is related to severe neutropenia, shock, and S. maltophilia pneumonia. [ncbi.nlm.nih.gov]
Neutropenia was confirmed as a risk factor for S. maltophilia bacteremia. [academic.oup.com]
Microbiology
- Pseudomonas
[…] heterotypic synonym Xanthomonas maltiphilia heterotypic synonym Pseudomonas beteli corrig. [ncbi.nlm.nih.gov]
PRODUCT Product Description Compounds Affinity compared to Stenotrophomonas maltophilia Stenotrophomonas maltophilia 1 Pseudomonas marginalis 150 Times Pseudomonas aeruginosa 400 Times Pseudomonas putida 1,500 Times Pseudomonas fluorescens 4,000 Times [genetex.com]
Pseudomonas maltophilia, an alcaligenes-like species. J. Gen. Microbiol. 26: 123-132, 1961. PubMed: 14449786 Ikemoto S, et al. Characterization of strains of Pseudomonas maltophilia which do not require methionine. Int. J. Syst. [lgcstandards-atcc.org]
Pleura
- Pleural Effusion
It was first found in a pleural effusion in 1943 and given the name Bacterium bookeri. It was then renamed to Pseudomonas maltophilia in 1961. [en.wikipedia.org]
effusions and cavitations are rarely observed.20 As many S maltophilia infections are polymicrobial, clinicians should be extremely cautious when interpreting radiological findings (especially in patients with cancer), as several copathogens (eg, Pseudomonas [journals.sagepub.com]
Pulmonary infiltrates on examination by radiology appear lobular-shaped and unusual pleural effusions. [24] In one of the retrospective studies carried out to analyse the effect of inhalation of tobramycin for the treatment of P. aeruginosa infections [ijmm.org]
Treatment
At that time, TMP/SMX was discontinued and treatment was initiated with intravenous doxycycline and aerosolized colistin. The VAP episode was cured after 14 days of treatment with doxycycline/aerosolized colistin. [ncbi.nlm.nih.gov]
The treatment of S. maltophilia can be problematic. [journals.plos.org]
Treatment of invasive S. maltophilia infections is difficult because this pathogen shows high levels of intrinsic or acquired resistance to different antimicrobial agents thus drastically reducing the antibiotic options available for treatment [ 1, 3, [ann-clinmicrob.biomedcentral.com]
Prognosis
These results suggest that more precise prediction and more appropriate treatment might improve the prognosis of patients with S. maltophilia bacteremia. [ncbi.nlm.nih.gov]
Etiology
The purpose of the present case report was to highlight this highly resistant microbe as an infectious etiology. [ncbi.nlm.nih.gov]
During the first year of renal replacement therapy, there were 3 episodes of peritonitis due to polymicrobial etiology, negative culture and Enterococcus faecalis, respectively. [revistanefrologia.com]
Epidemiology
The epidemiology of the organism is considered with particular reference to nosocomial outbreaks, several of which have been investigated by molecular typing techniques. [ncbi.nlm.nih.gov]
Infection control and Hospital Epidemiology. 19(12):911-914. [proeconomy.com]
Molecular epidemiology of Stenotrophomonas maltophilia in a university hospital. J Hosp Infect. 2002;52:88-92.19. Denton M, Todd NJ, Kerr KG, Hawkey PM, Littlewood JM. [siicsalud.com]
Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States. [pubmed.ncbi.nlm.nih.gov]
Pathophysiology
PATHOPHYSIOLOGY • S maltophilia has few pathogenic mechanisms and, for this reason, predominantly results in colonization rather than infection. [slideshare.net]
(Frost K, 2019) Also data from the EU CF registry confirm the relationship between CFRD and colonization by SM (Olesen HV, 2019) A recent review gathers all the current knowledge on the major pathophysiological traits, their supporting mechanisms, regulation [cfdb.eu]
Otherwise, the pathophysiology of this nonfermentative aerobic gram-negative bacillus does not differ from other nonfermentative aerobic organisms. Epidemiology Frequency United States S maltophilia is a noninvasive organism that has low virulence. [emedicine.medscape.com]
TNF-α signaling contributes significantly to the pathophysiology of S. maltophilia pneumonia, as reflected by the minimal disease observed in the TNFR1 null mice. [doi.org]
Prevention
Prevention Copper Silver Ionization is proven to be one of the most effective technologies for controlling and preventing S. Maltophilia in water systems. Do you know the facts? Although it is associated with high mortality rates in humans, S. [liquitech.com]
Removing the CVC and the combined antibiotics without preventing the neutrophil engraftment could avoid surgical drainage in pyomyositis due to S. maltophilia when detected in an early stage. [ncbi.nlm.nih.gov]
Strict sterilization procedures are required to prevent and control nosocomial contamination. [bmcinfectdis.biomedcentral.com]