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2.1
Subcutaneous Abscess
Pus-Filled Cavity below the Skin

A subcutaneous abscess is a pocket of pus formed in the superficial skin as a result of normal skin bacteria infiltrating broken or damaged skin. This type of skin infection develops anywhere on the body, but has a preference for intertriginous areas. A subcutaneous abscess is painful and appears as a swollen, erythematous, and fluctuant mass. The diagnosis is typically clinical unless the abscess is complex, something which would warrant a more extensive workup.

Presentation

A subcutaneous abscess is a pus-filled cavity located in the superficial skin layers caused by penetration of the skin by bacteria following a cut or other dermal disruption [1]. The implicated pathogens are normal skin flora bacteria [2] [3] such as Staphylococcus aureus (most common), group A Streptococcus, and anaerobes [2] [3] [4]. A subcutaneous abscess is circumscribed by tissue containing inflammatory cells and the purulent collection is composed of bacteria, immune cells, and material from the surrounding necrotic subcutaneous tissue [1]. Abscesses and other skin and soft tissue infections (SSTIs) are a common cause of visits to the emergency department and the doctor's office [5].

A subcutaneous abscess presents as a painful edematous mass with induration [4]. They typically form on regions in the body predisposed to friction, also known as intertriginous areas, although they can appear anywhere [6]. This may manifest as a furuncle, which emerges from a hair follicle, or carbuncles which are clusters of infected follicles [6]. Subcutaneous abscesses can rupture spontaneously in which the overlying skin on the abscess thins out and possibly becomes yellow or white, reflecting the pus collection.

Risk factors for abscesses and SSTIs, in general, include advanced age, trauma, diabetes mellitus, malignancy, immunocompromised state, obesity, and so forth [7] [8] [9]. Additionally, individuals such as athletes playing in close-contact sport and military individuals living in close proximity are predisposed to outbreaks [10] [11].

Physical exam

A superficial abscess is characterized by tenderness, warmth, erythema, and fluctuance. Note that generalized symptoms such as fever and chills do not occur with these simple abscesses [12].

Workup

The diagnosis of a subcutaneous abscess is clinical, which is based on patient history and focuses on risk factors and visual inspection of the abscess. Laboratory tests, such as complete blood count (CBC) and blood cultures, are reserved for severe and deep infections [4]. Moreover, blood cultures do not influence the management of simple abscesses, especially in healthy individuals [13] [14]. Imaging is not required for subcutaneous abscesses or other simple SSTIs [4].

Note that the workup for complicated SSTIs is extensive and includes needle aspiration of fluid and possibly tissue biopsy [15]. Blood cultures are indicated in patients with systemic involvement, deep tissue infections, and immunocompromised individuals[16] [17]. Furthermore, complicated cases may warrant imaging such as computed tomography (CT) scanning, which is the recommended study [18]. Ultrasonography, magnetic resonance imaging (MRI), and other modalities may be used for further evaluation if needed.

Treatment

The primary treatment for a subcutaneous abscess is drainage. This involves making a small incision in the skin to allow the pus to escape, relieving pressure and pain. In some cases, a healthcare provider may insert a small tube to keep the area open and ensure complete drainage. Antibiotics may be prescribed to treat the underlying infection, especially if the abscess is large, recurrent, or associated with systemic symptoms. Pain management and wound care are also important components of treatment.

Prognosis

With appropriate treatment, the prognosis for a subcutaneous abscess is generally good. Most abscesses resolve completely after drainage and antibiotic therapy. However, complications can occur if the abscess is not treated promptly, including the spread of infection to surrounding tissues or the bloodstream. Recurrence is possible, particularly in individuals with underlying conditions that predispose them to infections, such as diabetes or immune system disorders.

Etiology

Subcutaneous abscesses are typically caused by bacterial infections. The most common bacteria involved are Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), and Streptococcus species. These bacteria can enter the skin through cuts, abrasions, or other breaks in the skin barrier. Risk factors for developing an abscess include poor hygiene, compromised immune function, and certain chronic conditions.

Epidemiology

Subcutaneous abscesses are a common medical condition, affecting individuals of all ages and backgrounds. They are more prevalent in populations with higher rates of skin infections, such as those living in crowded or unsanitary conditions. Certain groups, including individuals with diabetes, those who are immunocompromised, and people with a history of skin infections, are at increased risk for developing abscesses.

Pathophysiology

The formation of a subcutaneous abscess begins with the invasion of bacteria into the skin. The body's immune response is activated, leading to the accumulation of white blood cells at the site of infection. These cells release enzymes that break down tissue, resulting in the formation of pus. The surrounding tissue becomes inflamed, causing the characteristic swelling, redness, and pain associated with an abscess.

Prevention

Preventing subcutaneous abscesses involves maintaining good personal hygiene, promptly treating skin injuries, and managing underlying health conditions. Regular handwashing, keeping skin clean and dry, and avoiding sharing personal items like towels or razors can reduce the risk of infection. For individuals with recurrent abscesses, addressing any predisposing factors, such as controlling blood sugar levels in diabetes, is crucial.

Summary

A subcutaneous abscess is a common and treatable condition characterized by a painful, pus-filled lump beneath the skin. Prompt diagnosis and treatment, typically involving drainage and antibiotics, are essential to prevent complications. Understanding the risk factors and maintaining good hygiene can help reduce the likelihood of developing an abscess.

Patient Information

If you suspect you have a subcutaneous abscess, it's important to seek medical attention. Look for signs such as a painful, swollen lump under the skin, redness, warmth, and possible drainage of pus. Treatment usually involves draining the abscess and may include antibiotics. Maintaining good hygiene and caring for any skin injuries can help prevent future abscesses.

References

  1. Townsend CM, Beauchamp RD, Mattox KL, Evers BM. Surgical Infections and Choice of Antibiotics. In: Sabiston Textbook of Surgery: the biological basis of modern surgical practice. 18th ed. Philadelphia,PA: Saunders Elsevier; 2007: 299-327.
  2. Brook I. Microbiology of polymicrobial abscesses and implications for therapy. J Antimicrob Chemother. 2002; 50(6):805-810.
  3. Dryden MS. Complicated skin and soft tissue infection. J Antimicrob Chemother. 2010;65(Suppl 3):iii35-44.
  4. Ramakrishnan K, Salinas RC, Agudelo Higuita NI. Skin and Soft Tissue Infections. Am Fam Physician. 2015;92(6):474-483.
  5. Hersh AL, Chambers HF, Maselli JH, Gonzales R. National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections. Arch Intern Med. 2008;168(14):1585–1591.
  6. Stulberg DL, Penrod MA, Blatny RA. Common Bacterial Skin Infections. Am Fam Physician. 2002;66(1):119-125.
  7. Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Can J Infect Dis Med Microbiol. 2008;19(2):173–184.
  8. Gabillot-Carré M, Roujeau JC. Acute bacterial skin infections and cellulitis. Curr Opin Infect Dis. 2007;20(2):118–123.
  9. Salgado CD, Farr BM, Calfee DP. Community-acquiredmethicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis. 2003;36(2):131–139.
  10. May L, Porter C, Tribble D. Self-reported incidence of skin and soft tissue infections among deployed US military. Travel Med Infect Dis. 2011;9(4):213–220.
  11. Decker CF. Skin and soft tissue infections in the athlete. Dis Mon. 2010;56(7):414–421.
  12. Long SS, Pickering LK, Prober CG. Subcutaneous Tissue Infections and Abscesses. In: Principles and Practice of Pediatric Infectious Diseases Revised Reprint. 3rd ed. New York: Elsevier; 2008:457-464.
  13. Payne CJ, Walker TW, Karcher AM, et al. Are routine microbiological investigations indicated in the management of non-perianal cutaneous abscesses? Surgeon. 2008;6(4):204–206.
  14. Mills AM, Chen EH. Are blood cultures necessary in adults with cellulitis? Ann Emerg Med. 2005;45(5):548–549.
  15. Breen JO. Skin and soft tissue infections in immunocompetent patients. Am Fam Physician. 2010;81(7):893-899.
  16. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections. Clin Infect Dis. 2014;59(2):e10–e52.
  17. Baron EJ, Miller JM, Weinstein MP, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases. Clin Infect Dis. 2013;57(4):e22–e121.
  18. Tayal VS, Hasan N, Norton HJ, et al. The effect of soft-tissue ultrasound on the management of cellulitis in the emergency department. Acad Emerg Med. 2006;13(4): 384-388.
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