Presentation
Chromosomal aberrations are present in half of all de novo MDS patients. [tandfonline.com]
Unbalanced rearrangements with additional sex chromosomes often present challenges for informed genetic counseling. [ncbi.nlm.nih.gov]
Entire Body System
- Pathologist
[…] definition of prognosis of patients with del(5q), and the observation that some groups of MDS patients with medullary blast counts above 20% generally have a prognosis similar to one with AML.5,10 The WHO classification has been more widely accepted by pathologists [tandfonline.com]
Treatment
[Clinical follow-up and treatment of patients with familial adenomatous polyposis]. Gastroenterol Clin Biol 2001; 25:B31–37. PubMed CAS Google Scholar Fotiadis C, Tsekouras DK, Antonakis P et al. [link.springer.com]
[…] clinicians, and was combined with the international prognostic scoring system,11 which utilizes the percentage medullary blasts, the number of cytopenic lines and cytogenetic abnormalities as prognostic factors, signifying an advance in the diagnosis and treatment [tandfonline.com]
Prognosis
[…] karyotype is associated with intermediate prognosis. [tandfonline.com]
The wide phenotypic variation and lack of long term follow-up reports in current literature make definitive prognosis for genetic counseling more challenging and problematic. [ncbi.nlm.nih.gov]