Presentation
Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity. Ophthalmology. 2008;115(2 Suppl.):S3–S12. [PubMed] [Google Scholar] 27. Kedar S., Jayagopal L.N., Berger J.R. [ncbi.nlm.nih.gov]
VUITY is not recommended to be used when iritis is present because adhesions (synechiae) may form between the iris and lens. [allerganeyecare.com]
Cardiovascular
- Hypotension
[…] syncope, or postural hypotension. [allerganeyecare.com]
- Hypertension
Non-ocular adverse reactions reported by greater than or equal to 5% of patients include: hypertension (13%) and bronchitis (5%). [allerganeyecare.com]
Eyes
- Anterior Uveitis
Clinical features of CMV-associated anterior uveitis. Ocul Immunol Inflamm. 2018;26(1):107–115. [PubMed] [Google Scholar] 48. Sun Y., Ji Y. A literature review on Fuchs uveitis syndrome: an update. Surv Ophthalmol. 2020;65(2):133–143. [ncbi.nlm.nih.gov]
Corticosteroid-containing preparations have also been reported to cause acute anterior uveitis and perforation of the globe. [allerganeyecare.com]
- Blurred Vision
Patients should be advised not to drive or operate machinery if vision is not clear (e.g., blurred vision). In addition, patients may experience temporary dim or dark vision with miotics, including VUITY. [allerganeyecare.com]
- Corneal Edema
Macular Edema Macular edema, including cystoid macular edema, has been reported during treatment with bimatoprost ophthalmic solution. [allerganeyecare.com]
- Foreign Body Sensation
Other reactions reported in 1% to 5% of patients included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance (most often blurring). [allerganeyecare.com]
- Photophobia
Other common adverse reactions reported in 5%-10% of patients were foreign body sensation, eye pain, photophobia, conjunctival hemorrhage, dry eye, eye irritation, intraocular pressure increased, corneal endothelial cell loss, vision blurred, iritis, [allerganeyecare.com]
Workup
Microbiology
- Streptococcus Pneumoniae
[…] mitis group *, Streptococcus oralis *, Streptococcus pneumoniae. [allerganeyecare.com]
Treatment
The increase in mean IOP was seen with each treatment cycle, and the mean IOP generally returned to baseline between treatment cycles (at the end of the 6-month period). [allerganeyecare.com]
Comparison of the efficacy and safety of valaciclovir and acyclovir for the treatment of herpes zoster ophthalmicus. Ophthalmology. 2000;107(8):1507–1511. [PubMed] [Google Scholar] 36. [ncbi.nlm.nih.gov]
Prognosis
Clinical manifestations, prognosis, and vaccination status of patients with rubella virus-associated uveitis. Am J Ophthalmol. 2019;202:37–46. [PubMed] [Google Scholar] 64. Quentin C.D., Reiber H. [ncbi.nlm.nih.gov]
Etiology
Chronic severe uveitis: etiology and visual outcome in 927 patients from a single center. Medicine. 2001;80(4):263–270. [PubMed] [Google Scholar] 20. Siddique S.S., Suelves A.M., Baheti U., Foster C.S. Glaucoma and uveitis. [ncbi.nlm.nih.gov]
Epidemiology
Epidemiology of Herpes Zoster ophthalmicus: recurrence and chronicity. Ophthalmology. 2016;123(7):1469–1475. [Article PMC gratuit] [PubMed] [Google Scholar] 40. Miserocchi E., Fogliato G., Bianchi I., Bandello F., Modorati G. [ncbi.nlm.nih.gov]
Prevention
Herpetic Eye Disease Study Group Acyclovir for the prevention of recurrent herpes simplex virus eye disease. N Engl J Med. 1998;339(5):300–306. [PubMed] [Google Scholar] 16. Farooq A.V., Shukla D. [ncbi.nlm.nih.gov]
To prevent eye injury or contamination, care should be taken to avoid touching the dispensing bottle to the eye or to any other surface. [allerganeyecare.com]